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Modulation of temperature-sensitive TRP channels
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Huang, Jiehong, Zhang, Xuming and McNaughton, Peter A. (2006) Modulation of temperature-sensitive TRP channels. Seminars in Cell & Developmental Biology, 17 (6). pp. 638-645. doi:10.1016/j.semcdb.2006.11.002 ISSN 1084-9521.
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Official URL: http://dx.doi.org/10.1016/j.semcdb.2006.11.002
Abstract
Animals sense temperature – either cold or hot – by the direct activation of temperature-sensitive members of the TRP family of ion channels, the thermo-TRPs. To date, six TRP channels – TRPV1–4, TRPM8 and TRPA1 – have been reported to be directly activated by heat and to be involved in thermosensation. Temperature sensing can be modulated by phosphorylation of intracellular residues by protein kinases or by insertion of new channels into the cell membrane. In this review we provide a brief overview of the properties of thermo-TRPs, and we summarise signalling pathways involved in their regulation.
Item Type: | Journal Article | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
Journal or Publication Title: | Seminars in Cell & Developmental Biology | ||||
Publisher: | Elsevier Ltd | ||||
ISSN: | 1084-9521 | ||||
Official Date: | December 2006 | ||||
Dates: |
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Volume: | 17 | ||||
Number: | 6 | ||||
Page Range: | pp. 638-645 | ||||
DOI: | 10.1016/j.semcdb.2006.11.002 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
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