Exploration of cellular reaction systems
Kirkilionis, Markus, 1962-. (2010) Exploration of cellular reaction systems. Briefings in Bioinformatics, Vol.11 (No.1). pp. 153-178. ISSN 1467-5463Full text not available from this repository.
Official URL: http://dx.doi.org/10.1093/bib/bbp062
We discuss and review different ways to map cellular components and their temporal interaction with other such components to different non-spatially explicit mathematical models. The essential choices made in the literature are between discrete and continuous state spaces, between rule and event-based state updates and between deterministic and stochastic series of such updates. The temporal modelling of cellular regulatory networks (dynamic network theory) is compared with static network approaches in two first introductory sections on general network modelling. We concentrate next on deterministic rate-based dynamic regulatory networks and their derivation. In the derivation, we include methods from multiscale analysis and also look at structured large particles, here called macromolecular machines. It is clear that mass-action systems and their derivatives, i.e. networks based on enzyme kinetics, play the most dominant role in the literature. The tools to analyse cellular reaction networks are without doubt most complete for mass-action systems. We devote a long section at the end of the review to make a comprehensive review of related tools and mathematical methods. The emphasis is to show how cellular reaction networks can be analysed with the help of different associated graphs and the dissection into modules, i.e. sub-networks.
|Item Type:||Journal Article|
|Subjects:||Q Science > QD Chemistry
T Technology > TP Chemical technology
|Divisions:||Faculty of Science > Mathematics|
|Journal or Publication Title:||Briefings in Bioinformatics|
|Publisher:||Oxford University Press|
|Number of Pages:||26|
|Page Range:||pp. 153-178|
|Access rights to Published version:||Restricted or Subscription Access|
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