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Brain functional connectivities that mediate the association between childhood traumatic events, and adult mental health and cognition
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Wan, Zhuo, Rolls, Edmund T., Feng, Jianfeng and Cheng, Wei (2022) Brain functional connectivities that mediate the association between childhood traumatic events, and adult mental health and cognition. eBioMedicine, 79 . 104002. doi:10.1016/j.ebiom.2022.104002 ISSN 2352-3964.
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WRAP-Brain-functional-connectivities-that-mediate-the-association-between-childhood-traumatic-events-Rolls-2022.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. Download (2684Kb) | Preview |
Official URL: http://dx.doi.org/10.1016/j.ebiom.2022.104002
Abstract
Background
Childhood traumatic events are risk factors for psychopathology, but large-scale studies of how childhood traumatic events relate to mental health and cognition in adulthood, and how the brain is involved, are needed.
Methods
The associations between childhood traumatic events (such as abuse and neglect, and defined by the ‘Childhood Trauma’ questions in the UK Biobank database) and brain functional connectivity, mental health problems, and cognitive performance were investigated by a univariate correlation analysis with 19,535 participants aged 45–79 from the UK Biobank dataset. The results were replicated with 17,747 independent participants in the second release from the same dataset.
Findings
Childhood traumatic events were significantly associated with mental health problems in adulthood including anxiety (r=0.19, p<1.0 × 10−323), depression (r=0.21, p<1.0 × 10−323), and self-harm (r=0.24, p<1.0 × 10−323), and with adult cognitive performance including fluid intelligence (r=−0.05, p=2.8 × 10−10) and prospective memory (r=−0.04, p=6.8 × 10−8). Functional connectivities of the medial and lateral temporal cortex, the precuneus, the medial orbitofrontal cortex; and the superior, middle and inferior prefrontal cortex extending back to precentral regions were negatively correlated with the childhood traumatic events (FDR corrected, p<0.01). These lower functional connectivities significantly mediated the associations between childhood traumatic events and addiction, anxiety, depression and well-being (all p<1.0 × 10−3), and cognitive performance. The association between childhood traumatic events and behavioural measures and functional connectivity were confirmed in a replication with different participants in the second release of the UK Biobank dataset.
Interpretation
Childhood traumatic events are strongly associated with adult mental health problems mediated by brain functional connectivities in brain areas involved in executive function, emotion, face processing, and memory. This understanding may help with prevention and treatment.
Item Type: | Journal Article | |||||||||
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Subjects: | Q Science > QP Physiology R Medicine > RJ Pediatrics |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science | |||||||||
Library of Congress Subject Headings (LCSH): | Psychic trauma in children, Child psychotherapy, Cognition disorders, Mental illness, Frontal lobes, Depression, Mental, Emotions | |||||||||
Journal or Publication Title: | eBioMedicine | |||||||||
Publisher: | Elsevier BV | |||||||||
ISSN: | 2352-3964 | |||||||||
Official Date: | 1 May 2022 | |||||||||
Dates: |
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Volume: | 79 | |||||||||
Number of Pages: | 14 | |||||||||
Article Number: | 104002 | |||||||||
DOI: | 10.1016/j.ebiom.2022.104002 | |||||||||
Status: | Peer Reviewed | |||||||||
Publication Status: | Published | |||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||
Date of first compliant deposit: | 23 May 2022 | |||||||||
Date of first compliant Open Access: | 24 May 2022 | |||||||||
RIOXX Funder/Project Grant: |
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