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Association of life course adiposity with risk of incident dementia : a prospective cohort study of 322,336 participants
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Deng, Yue-Ting, Li, Yu-Zhu, Huang, Shu-Yi, Ou, Ya-Nan, Zhang, Wei, Chen, Shi-Dong, Zhang, Ya-Ru, Yang, Liu, Dong, Qiang, Feng, Jianfeng, Suckling, John, Smith, A. David, Cheng, Wei and Yu, Jin-Tai (2022) Association of life course adiposity with risk of incident dementia : a prospective cohort study of 322,336 participants. Molecular Psychiatry, 27 . pp. 3385-3395. doi:10.1038/s41380-022-01604-9 ISSN 1359-4184.
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Official URL: https://doi.org/10.1038/s41380-022-01604-9
Abstract
Cohort studies report inconsistent associations between body mass index (BMI) and all-cause incident dementia. Furthermore, evidence on fat distribution and body composition measures are scarce and few studies estimated the association between early life adiposity and dementia risk. Here, we included 322,336 participants from UK biobank to investigate the longitudinal association between life course adiposity and risk of all-cause incident dementia and to explore the underlying mechanisms driven by metabolites, inflammatory cells and brain structures. Among the 322,336 individuals (mean (SD) age, 62.24 (5.41) years; 53.9% women) in the study, during a median 8.74 years of follow-up, 5083 all-cause incident dementia events occurred. The risk of dementia was 22% higher with plumper childhood body size (p < 0.001). A strong U-shaped association was observed between adult BMI and dementia. More fat and less fat-free mass distribution on arms were associated with a higher risk of dementia. Interestingly, similar U-shaped associations were found between BMI and four metabolites (i.e., 3-hydroxybutrate, acetone, citrate and polyunsaturated fatty acids), four inflammatory cells (i.e., neutrophil, lymphocyte, monocyte and leukocyte) and abnormalities in brain structure that were also related to dementia. The findings that adiposity is associated with metabolites, inflammatory cells and abnormalities in brain structure that were related to dementia risk might provide clues to underlying biological mechanisms. Interventions to prevent dementia should begin early in life and include not only BMI control but fat distribution and body composition. [Abstract copyright: © 2022. The Author(s), under exclusive licence to Springer Nature Limited.]
Item Type: | Journal Article | ||||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science | ||||||||
SWORD Depositor: | Library Publications Router | ||||||||
Journal or Publication Title: | Molecular Psychiatry | ||||||||
Publisher: | Nature Publishing Group | ||||||||
ISSN: | 1359-4184 | ||||||||
Official Date: | August 2022 | ||||||||
Dates: |
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Volume: | 27 | ||||||||
Page Range: | pp. 3385-3395 | ||||||||
DOI: | 10.1038/s41380-022-01604-9 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access |
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