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Albumin-mediated extracellular zinc speciation drives cellular zinc uptake
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Coverdale, James P. C., Van Den Berg, Hugo, Khazaipoul, Siavash, Bridgewater, Hannah E., Stewart, Alan J. and Blindauer, Claudia A. (2022) Albumin-mediated extracellular zinc speciation drives cellular zinc uptake. Chemical Communications, 58 (53). pp. 7384-7387. doi:10.1039/D2CC02278H ISSN 1359-7345.
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WRAP-Albumin-mediated-extracellular-zinc-speciation-drives-cellular-zinc-2022.pdf - Accepted Version - Requires a PDF viewer. Download (930Kb) | Preview |
Official URL: https://doi.org/10.1039/D2CC02278H
Abstract
The role of the extracellular medium in influencing metal uptake into cells has not been described quantitatively. In a chemically-defined model system containing albumin, zinc influx into endothelial cells correlates with the extracellular free zinc concentration. Allosteric inhibition of zinc-binding to albumin by free fatty acids increased zinc flux.
| Item Type: | Journal Article | ||||||||||||
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| Subjects: | Q Science > QP Physiology | ||||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Science > Mathematics |
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| Library of Congress Subject Headings (LCSH): | Zinc in the body, Vascular endothelial cells, Albumins | ||||||||||||
| Journal or Publication Title: | Chemical Communications | ||||||||||||
| Publisher: | Royal Society of Chemistry | ||||||||||||
| ISSN: | 1359-7345 | ||||||||||||
| Official Date: | 7 July 2022 | ||||||||||||
| Dates: |
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| Volume: | 58 | ||||||||||||
| Number: | 53 | ||||||||||||
| Page Range: | pp. 7384-7387 | ||||||||||||
| DOI: | 10.1039/D2CC02278H | ||||||||||||
| Status: | Peer Reviewed | ||||||||||||
| Publication Status: | Published | ||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||
| Date of first compliant deposit: | 26 May 2022 | ||||||||||||
| Date of first compliant Open Access: | 2 June 2023 | ||||||||||||
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