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Polymeric nanotubes as drug delivery vectors─comparison of covalently and supramolecularly assembled constructs
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Kerr, Andrew, Sagita, Erny, Mansfield, Edward D. H., Nguyen, Tri-Hung, Feeney, Orlagh M., Pouton, Colin W., Porter, Christopher J. H., Sanchis, Joaquin and Perrier, Sébastien (2022) Polymeric nanotubes as drug delivery vectors─comparison of covalently and supramolecularly assembled constructs. Biomacromolecules, 23 (6). pp. 2315-2328. doi:10.1021/acs.biomac.2c00063 ISSN 1526-4602.
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Official URL: https://doi.org/10.1021/acs.biomac.2c00063
Abstract
Rod-shaped nanoparticles have been identified as promising drug delivery candidates. In this report, the in vitro cell uptake and in vivo pharmacokinetic/bio-distribution behavior of molecular bottle-brush (BB) and cyclic peptide self-assembled nanotubes were studied in the size range of 36–41 nm in length. It was found that BB possessed the longest plasma circulation time (t1\2 > 35 h), with the cyclic peptide system displaying an intermediate half-life (14.6 h), although still substantially elevated over a non-assembling linear control (2.7 h). The covalently bound BB underwent substantial distribution into the liver, whereas the cyclic peptide nanotube was able to mostly circumvent organ accumulation, highlighting the advantage of the inherent degradability of the cyclic peptide systems through their reversible aggregation of hydrogen bonding core units.
| Item Type: | Journal Article | ||||||||
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||
| SWORD Depositor: | Library Publications Router | ||||||||
| Journal or Publication Title: | Biomacromolecules | ||||||||
| Publisher: | American Chemical Society (ACS) | ||||||||
| ISSN: | 1526-4602 | ||||||||
| Official Date: | 13 June 2022 | ||||||||
| Dates: |
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| Volume: | 23 | ||||||||
| Number: | 6 | ||||||||
| Page Range: | pp. 2315-2328 | ||||||||
| DOI: | 10.1021/acs.biomac.2c00063 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Reuse Statement (publisher, data, author rights): | ** Article version: VoR ** From Crossref journal articles via Jisc Publications Router ** History: epub 18-05-2022; issued 18-05-2022. ** Licence for VoR version of this article starting on 18-05-2022: https://creativecommons.org/licenses/by/4.0/ | ||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||
| Copyright Holders: | Copyright © 2022 The Authors. Published by American Chemical Society | ||||||||
| Date of first compliant deposit: | 11 July 2022 | ||||||||
| Date of first compliant Open Access: | 11 July 2022 | ||||||||
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