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Differences in composition of interdigital skin microbiota predict sheep and feet that develop footrot
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Clifton, Rachel, Monaghan, Emma M., Green, Martin J., Purdy, Kevin J. and Green, Laura E. (2022) Differences in composition of interdigital skin microbiota predict sheep and feet that develop footrot. Scientific Reports, 12 (1). 8931. doi:10.1038/s41598-022-12772-7 ISSN 2045-2322.
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WRAP-Differences-interdigital-skin-microbiota-sheep-feet-footrot-2022.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1555Kb) | Preview |
Official URL: https://doi.org/10.1038/s41598-022-12772-7
Abstract
Footrot has a major impact on health and productivity of sheep worldwide. The current paradigm for footrot pathogenesis is that physical damage to the interdigital skin (IDS) facilitates invasion of the essential pathogen Dichelobacter nodosus. The composition of the IDS microbiota is different in healthy and diseased feet, so an alternative hypothesis is that changes in the IDS microbiota facilitate footrot. We investigated the composition and diversity of the IDS microbiota of ten sheep, five that did develop footrot and five that did not (healthy) at weekly intervals for 20 weeks. The IDS microbiota was less diverse on sheep 2 + weeks before they developed footrot than on healthy sheep. This change could be explained by only seven of > 2000 bacterial taxa detected. The incubation period of footrot is 8–10 days, and there was a further reduction in microbial diversity on feet that developed footrot in that incubation period. We conclude that there are two stages of dysbiosis in footrot: the first predisposes sheep to footrot and the second occurs in feet during the incubation of footrot. These findings represent a step change in our understanding of the role of the IDS microbiota in footrot pathogenesis.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Subjects: | S Agriculture > SF Animal culture | ||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
| SWORD Depositor: | Library Publications Router | ||||||
| Library of Congress Subject Headings (LCSH): | Sheep -- Diseases, Footrot in sheep, Ruminants -- Diseases, Dichelobacter nodosus | ||||||
| Journal or Publication Title: | Scientific Reports | ||||||
| Publisher: | Nature Publishing Group UK | ||||||
| ISSN: | 2045-2322 | ||||||
| Official Date: | 27 May 2022 | ||||||
| Dates: |
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| Volume: | 12 | ||||||
| Number: | 1 | ||||||
| Article Number: | 8931 | ||||||
| DOI: | 10.1038/s41598-022-12772-7 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||
| Date of first compliant deposit: | 17 June 2022 | ||||||
| Date of first compliant Open Access: | 17 June 2022 | ||||||
| RIOXX Funder/Project Grant: |
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