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Venous thromboembolism rate in patients with bladder cancer according to the type of treatment: a systematic review

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Abdullah, Omar, Parashar, Deepak, Mustafa, Israa J. and Young, Annie M. (2022) Venous thromboembolism rate in patients with bladder cancer according to the type of treatment: a systematic review. Cureus, 14 (3). e22945. doi:10.7759/cureus.22945

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Official URL: https://doi.org/10.7759/cureus.22945

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Abstract

Bladder cancer (BC) is classified as a high-risk tumour type for venous thromboembolism (VTE). VTE presents an extra challenge in the management of patients with cancer, given the increase in morbidity and mortality on having both conditions.

To summarise the contemporary evidence on the VTE rate in patients with BC according to the stage, type of anti-cancer treatment and highlight VTE rate in the UK and other countries. A systematic review was carried out, and an electronic search for publications between January 2000 and November 2021 was done. Studies recording VTE in BC patients were included, whilst paediatric patients, case reports, studies reporting on a mix of arterial and venous thrombosis, studies reporting DVT or PE only and recorded hospitalised VTE only were excluded. The rate of VTE, country of origin, risk factors and thromboprophylaxis duration for VTE in BC patients were identified.

A total of 38 papers met the search criteria. All publications were original research papers (cohort studies). The overall VTE rate in patients with BC was estimated at 1.9% to 4.7%. For those patients undergoing cystectomy, the VTE rate ranged from 3% to 17.6%; however, the VTE rate in the metastatic stage of BC patients ranged from 3.1% to 5.1%.

The rates of VTE in BC patients are high, further increased by interventions such as surgery and chemotherapy. Thromboprophylaxis measures should be optimised. This review highlighted the fact that the VTE rate in BC varies between studies due to the heterogeneity of risk factors reported.

Item Type: Journal Article
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RZ Other systems of medicine
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Statistics and Epidemiology
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Bladder -- Cancer -- Patients -- Treatment, Thrombophlebitis , Thromboembolism, Thromboembolism -- Chemotherapy
Journal or Publication Title: Cureus
Publisher: Cureus
ISSN: 2168-8184
Official Date: 8 March 2022
Dates:
DateEvent
8 March 2022Published
4 March 2022Accepted
Volume: 14
Number: 3
Number of Pages: 14
Article Number: e22945
DOI: 10.7759/cureus.22945
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access

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