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Emerging role of mechanical forces in cell fate acquisition
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Alvarez, Yanina and Smutny, Michael (2022) Emerging role of mechanical forces in cell fate acquisition. Frontiers in Cell and Developmental Biology, 10 . 864522. doi:10.3389/fcell.2022.864522 ISSN 2296-634X.
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Official URL: https://doi.org/10.3389/fcell.2022.864522
Abstract
Mechanical forces are now recognized as key cellular effectors that together with genetic and cellular signals physically shape and pattern tissues and organs during development. Increasing efforts are aimed toward understanding the less explored role of mechanical forces in controlling cell fate decisions in embryonic development. Here we discuss recent examples of how differential forces feedback into cell fate specification and tissue patterning. In particular, we focus on the role of actomyosin-contractile force generation and transduction in affecting tissue morphogenesis and cell fate regulation in the embryo.
Item Type: | Journal Article | ||||||||||||
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Subjects: | Q Science > QH Natural history > QH301 Biology Q Science > QM Human anatomy |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||||||||||
SWORD Depositor: | Library Publications Router | ||||||||||||
Library of Congress Subject Headings (LCSH): | Morphogenesis, Cell differentiation, Cell determination, Embryology, Human | ||||||||||||
Journal or Publication Title: | Frontiers in Cell and Developmental Biology | ||||||||||||
Publisher: | Frontiers Media S.A. | ||||||||||||
ISSN: | 2296-634X | ||||||||||||
Official Date: | 23 May 2022 | ||||||||||||
Dates: |
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Volume: | 10 | ||||||||||||
Article Number: | 864522 | ||||||||||||
DOI: | 10.3389/fcell.2022.864522 | ||||||||||||
Status: | Peer Reviewed | ||||||||||||
Publication Status: | Published | ||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||
Date of first compliant deposit: | 28 June 2022 | ||||||||||||
Date of first compliant Open Access: | 28 June 2022 | ||||||||||||
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