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A family of externally-functionalised coordination cages
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Jackson, Garrett D., Tipping, Max B., Taylor, Christopher G. P., Piper, Jerico R., Pritchard, Callum, Mozaceanu, Cristina and Ward, Michael D. (2021) A family of externally-functionalised coordination cages. Chemistry, 3 (4). pp. 1203-1214. doi:10.3390/chemistry3040088 ISSN 2624-8549.
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Official URL: http://dx.doi.org/10.3390/chemistry3040088
Abstract
New synthetic routes are presented to derivatives of a (known) M8L12 cubic coordination cage in which a range of different substituents are attached at the C4 position of the pyridyl rings at either end of the bis(pyrazolyl-pyridine) bridging ligands. The substituents are (i) –CN groups (new ligand LCN), (ii) –CH2OCH2–CCH (containing a terminal alkyne) groups (new ligand LCC); and (iii) –(CH2OCH2)3CH2OMe (tri-ethyleneglycol monomethyl ether) groups (new ligand LPEG). The resulting functionalised ligands combine with M2+ ions (particularly Co2+, Ni2+, Cd2+) to give isostructural [M8L12]16+ cage cores bearing 24 external functional groups; the cages based on LCN (with M2+ = Cd2+) and LCC (with M2+ = Ni2+) have been crystallographically characterised. The value of these is twofold: (i) exterior nitrile or alkene substituents can provide a basis for further synthetic opportunities via ‘Click’ reactions allowing in principle a diverse range of functionalisation of the cage exterior surface; (ii) the exterior –(CH2OCH2)3CH2OMe groups substantially increase cage solubility in both water and in organic solvents, allowing binding constants of cavity-binding guests to be measured under an increased range of conditions.
| Item Type: | Journal Article | |||||||||||||||
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| Subjects: | Q Science > QD Chemistry | |||||||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | |||||||||||||||
| Library of Congress Subject Headings (LCSH): | Coordination compounds, Crystals -- Structure, X-ray crystallography, Chemistry, Organic | |||||||||||||||
| Journal or Publication Title: | Chemistry | |||||||||||||||
| Publisher: | MDPI | |||||||||||||||
| ISSN: | 2624-8549 | |||||||||||||||
| Official Date: | 14 October 2021 | |||||||||||||||
| Dates: |
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| Volume: | 3 | |||||||||||||||
| Number: | 4 | |||||||||||||||
| Page Range: | pp. 1203-1214 | |||||||||||||||
| DOI: | 10.3390/chemistry3040088 | |||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||
| Publication Status: | Published | |||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||
| Date of first compliant deposit: | 7 June 2022 | |||||||||||||||
| Date of first compliant Open Access: | 9 June 2022 | |||||||||||||||
| RIOXX Funder/Project Grant: |
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