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A single sensor controls large variations in zinc quotas in a marine cyanobacterium

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Mikhaylina, Alevtina, Ksibe, Amira Z., Wilkinson, Rachael C., Smith, Darbi, Marks, Eleanor, Coverdale, James P. C., Fülöp, Vilmos, Scanlan, David J. and Blindauer, Claudia A. (2022) A single sensor controls large variations in zinc quotas in a marine cyanobacterium. Nature Chemical Biology, 18 . pp. 869-877. doi:10.1038/s41589-022-01051-1

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Official URL: http://dx.doi.org/10.1038/s41589-022-01051-1

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Abstract

Marine cyanobacteria are critical players in global nutrient cycles that crucially depend on trace metals in metalloenzymes, including zinc for CO2 fixation and phosphorus acquisition. How strains proliferating in the vast oligotrophic ocean gyres thrive at ultra-low zinc concentrations is currently unknown. Using Synechococcus sp. WH8102 as a model we show that its zinc-sensor protein Zur differs from all other known bacterial Zur proteins in overall structure and the location of its sensory zinc site. Uniquely, Synechococcus Zur activates metallothionein gene expression, which supports cellular zinc quotas spanning two orders of magnitude. Thus, a single zinc sensor facilitates growth across pico- to micromolar zinc concentrations with the bonus of banking this precious resource. The resultant ability to grow well at both ultra-low and excess zinc, together with overall lower zinc requirements, likely contribute to the broad ecological distribution of Synechococcus across the global oceans.

Item Type: Journal Article
Subjects: Q Science > QP Physiology
Q Science > QR Microbiology
Divisions: Faculty of Science, Engineering and Medicine > Science > Chemistry
Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Cyanobacteria, Marine bacteria -- Research, Metalloenzymes
Journal or Publication Title: Nature Chemical Biology
Publisher: Nature Publishing Group
ISSN: 1552-4450
Official Date: August 2022
Dates:
DateEvent
August 2022Published
9 June 2022Available
5 May 2022Accepted
Volume: 18
Page Range: pp. 869-877
DOI: 10.1038/s41589-022-01051-1
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
Chancellor’s International ScholarshipUniversity of Warwickhttp://dx.doi.org/10.13039/501100000741
BB/M003523/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
NE/I00985X/1[NERC] Natural Environment Research Councilhttp://dx.doi.org/10.13039/501100000270

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