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A single sensor controls large variations in zinc quotas in a marine cyanobacterium
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Mikhaylina, Alevtina, Ksibe, Amira Z., Wilkinson, Rachael C., Smith, Darbi, Marks, Eleanor, Coverdale, James P. C., Fülöp, Vilmos, Scanlan, David J. and Blindauer, Claudia A. (2022) A single sensor controls large variations in zinc quotas in a marine cyanobacterium. Nature Chemical Biology, 18 . pp. 869-877. doi:10.1038/s41589-022-01051-1
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WRAP-single-sensor-controls-large-variations-zinc-quotas-marine-cyanobacterium-2022.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (18Mb) | Preview |
Official URL: http://dx.doi.org/10.1038/s41589-022-01051-1
Abstract
Marine cyanobacteria are critical players in global nutrient cycles that crucially depend on trace metals in metalloenzymes, including zinc for CO2 fixation and phosphorus acquisition. How strains proliferating in the vast oligotrophic ocean gyres thrive at ultra-low zinc concentrations is currently unknown. Using Synechococcus sp. WH8102 as a model we show that its zinc-sensor protein Zur differs from all other known bacterial Zur proteins in overall structure and the location of its sensory zinc site. Uniquely, Synechococcus Zur activates metallothionein gene expression, which supports cellular zinc quotas spanning two orders of magnitude. Thus, a single zinc sensor facilitates growth across pico- to micromolar zinc concentrations with the bonus of banking this precious resource. The resultant ability to grow well at both ultra-low and excess zinc, together with overall lower zinc requirements, likely contribute to the broad ecological distribution of Synechococcus across the global oceans.
| Item Type: | Journal Article | ||||||||||||
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| Subjects: | Q Science > QP Physiology Q Science > QR Microbiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) |
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| Library of Congress Subject Headings (LCSH): | Cyanobacteria, Marine bacteria -- Research, Metalloenzymes | ||||||||||||
| Journal or Publication Title: | Nature Chemical Biology | ||||||||||||
| Publisher: | Nature Publishing Group | ||||||||||||
| ISSN: | 1552-4450 | ||||||||||||
| Official Date: | August 2022 | ||||||||||||
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| Volume: | 18 | ||||||||||||
| Page Range: | pp. 869-877 | ||||||||||||
| DOI: | 10.1038/s41589-022-01051-1 | ||||||||||||
| Status: | Peer Reviewed | ||||||||||||
| Publication Status: | Published | ||||||||||||
| Access rights to Published version: | Open Access | ||||||||||||
| RIOXX Funder/Project Grant: |
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