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Acceptability of donor funding for clinical trials in the UK : a qualitative empirical ethics study using focus groups to elicit the views of research patient public involvement group members, research ethics committee chairs and clinical researchers
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Shearman, Kirstie, Masters, Alexander, Nutt, Dominic, Bowman, Simon and Draper, Heather (2022) Acceptability of donor funding for clinical trials in the UK : a qualitative empirical ethics study using focus groups to elicit the views of research patient public involvement group members, research ethics committee chairs and clinical researchers. BMJ Open, 12 (6). e055208. doi:10.1136/bmjopen-2021-055208 ISSN 2044-6055.
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Official URL: https://doi.org/10.1136/bmjopen-2021-055208
Abstract
Objectives
The Plutocratic Proposal is a novel method of funding early phase, clinical trials where a single donor funds the entire trial and in so doing secures a place on it. The aim of this study was to identify and explore concerns that may be raised by UK research ethics committees (RECs) when reviewing clinical trials funded in this way.
Design
Empirical ethics combining ethical analysis and qualitative data from three focus groups held online using Frith’s symbiotic approach. Data were analysed using inductive thematic approach informed by the study aims and ethical analysis.
Participants 22 participants were recruited: 8 research patient public involvement group members, 7 REC chairs and 7 clinical researchers.
All were based in the UK.
Results
With one exception, participants thought the Plutocratic Proposal may be ‘all things considered’ acceptable, providing their concerns were met, primary of which was upholding scientific integrity. Other concerns discussed related to the acceptability of the donor securing a place on the trail including: whether this was unfair distribution of benefits, disclosing the identity of the donor as the funder, protecting the donor from exploitation and funding a single study with multiple donors on the same terms. Some misgivings fell outside the usual REC purview: detrimental impact of donors of bad character, establishing the trustworthiness of matching agency and its processes and optimising research funding and resources. Despite their concerns, participants recognised that because the donor funds the whole trial, others would also potentially benefit from participating.
Conclusions
We identified concerns about the Plutocratic Proposal. UK RECs may be open to approving studies if these can be addressed. Existing governance processes will do some of this work, but additional REC guidance, particularly in relation to donors securing a place on the trial, may be necessary to help RECs navigate ethical concerns consistently.
| Item Type: | Journal Article | ||||||||
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| Subjects: | H Social Sciences > HM Sociology Q Science > Q Science (General) |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Research, Participant observation, Research -- Moral and ethical aspects, Focus groups | ||||||||
| Journal or Publication Title: | BMJ Open | ||||||||
| Publisher: | BMJ | ||||||||
| ISSN: | 2044-6055 | ||||||||
| Official Date: | 17 June 2022 | ||||||||
| Dates: |
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| Volume: | 12 | ||||||||
| Number: | 6 | ||||||||
| Number of Pages: | 10 | ||||||||
| Article Number: | e055208 | ||||||||
| DOI: | 10.1136/bmjopen-2021-055208 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||
| Date of first compliant deposit: | 14 June 2022 | ||||||||
| Date of first compliant Open Access: | 14 June 2022 | ||||||||
| RIOXX Funder/Project Grant: |
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