The Library
Low levels of factor H family proteins during meningococcal disease indicate systemic processes rather than specific depletion by Neisseria meningitidis
Tools
van Beek, Anna E., Pouw, Richard B., Wright, Victoria J., Sallah, Neneh, Inwald, David, Hoggart, Clive, Brouwer, Mieke C., Galassini, Rachel, Thomas, John, Calvo-Bado, Leo A., Fink, Colin, Jongerius, Ilse, Hibberd, Martin, Wouters, Diana, Levin, Michael and Kuijpers, Taco W. (2022) Low levels of factor H family proteins during meningococcal disease indicate systemic processes rather than specific depletion by Neisseria meningitidis. Frontiers in Immunology, 13 . 876776. doi:10.3389/fimmu.2022.876776 ISSN 1664-3224.
|
PDF
WRAP-low-levels-factor-H-family-proteins-during-meningococcal-disease-indicate-systemic-processes-rather-than-specific-depletion-Neisseria-meningitidis-2022.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (5Mb) | Preview |
Official URL: https://doi.org/10.3389/fimmu.2022.876776
Abstract
Neisseria meningitidis, the causative agent of meningococcal disease (MD), evades complement-mediated clearance upon infection by ‘hijacking’ the human complement regulator factor H (FH). The FH protein family also comprises the homologous FH-related (FHR) proteins, hypothesized to act as antagonists of FH, and FHR-3 has recently been implicated to play a major role in MD susceptibility. Here, we show that the circulating levels of all FH family proteins, not only FH and FHR-3, are equally decreased during the acute illness. We did neither observe specific consumption of FH or FHR-3 by N. meningitidis, nor of any of the other FH family proteins, suggesting that the globally reduced levels are due to systemic processes including dilution by fluid administration upon admission and vascular leakage. MD severity associated predominantly with a loss of FH rather than FHRs. Additionally, low FH levels associated with renal failure, suggesting insufficient protection of host tissue by the active protection by the FH protein family, which is reminiscent of reduced FH activity in hemolytic uremic syndrome. Retaining higher levels of FH may thus limit tissue injury during MD.
Item Type: | Journal Article | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Subjects: | Q Science > QR Microbiology | ||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||||||
SWORD Depositor: | Library Publications Router | ||||||||||||
Library of Congress Subject Headings (LCSH): | Neisseria meningitidis -- Research, Meningococcal infections, Immunology | ||||||||||||
Journal or Publication Title: | Frontiers in Immunology | ||||||||||||
Publisher: | Frontiers Research Foundation | ||||||||||||
ISSN: | 1664-3224 | ||||||||||||
Official Date: | 26 May 2022 | ||||||||||||
Dates: |
|
||||||||||||
Volume: | 13 | ||||||||||||
Article Number: | 876776 | ||||||||||||
DOI: | 10.3389/fimmu.2022.876776 | ||||||||||||
Status: | Peer Reviewed | ||||||||||||
Publication Status: | Published | ||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||
Date of first compliant deposit: | 8 December 2022 | ||||||||||||
Date of first compliant Open Access: | 8 December 2022 | ||||||||||||
RIOXX Funder/Project Grant: |
|
||||||||||||
Contributors: |
|
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year