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Structure, function and druggability of the African trypanosome flagellum
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Sáez Conde, Julia and Dean, Samuel (2022) Structure, function and druggability of the African trypanosome flagellum. Journal of Cellular Physiology, 237 (6). pp. 2654-2667. doi:10.1002/jcp.30778
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Official URL: http://dx.doi.org/10.1002/jcp.30778
Abstract
African trypanosomes are early branching protists that cause human and animal diseases, termed trypanosomiases. They have been under intensive study for more than 100 years and have contributed significantly to our understanding of eukaryotic biology. The combination of conserved and parasite-specific features mean that their flagellum has gained particular attention. Here, we discuss the different structural features of the flagellum and their role in transmission and virulence. We highlight the possibilities of targeting flagellar function to cure trypanosome infections and help in the fight to eliminate trypanosomiases.
| Item Type: | Journal Item | ||||||||||
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| Subjects: | Q Science > QL Zoology Q Science > QR Microbiology R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | African trypanosomiasis, Chemotherapy, Flagella (Microbiology), Parasites, Trypanosomiasis | ||||||||||
| Journal or Publication Title: | Journal of Cellular Physiology | ||||||||||
| Publisher: | Wiley | ||||||||||
| ISSN: | 0021-9541 | ||||||||||
| Official Date: | June 2022 | ||||||||||
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| Volume: | 237 | ||||||||||
| Number: | 6 | ||||||||||
| Number of Pages: | 14 | ||||||||||
| Page Range: | pp. 2654-2667 | ||||||||||
| DOI: | 10.1002/jcp.30778 | ||||||||||
| Status: | Peer Reviewed | ||||||||||
| Publication Status: | Published | ||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||||
| Date of first compliant deposit: | 20 June 2022 | ||||||||||
| Date of first compliant Open Access: | 21 June 2022 | ||||||||||
| RIOXX Funder/Project Grant: |
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