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Minimalistic ice recrystallisation inhibitors based on phenylalanine
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Warren, Matthew T., Galpin, Iain, Hasan, Muhammad, Hindmarsh, Steven A., Padrnos, John D., Edwards-Gayle, Charlotte, Mathers, Robert T., Adams, Dave J., Sosso, Gabriele C. and Gibson, Matthew I. (2022) Minimalistic ice recrystallisation inhibitors based on phenylalanine. Chemical Communications, 58 (55). pp. 7658-7661. doi:10.1039/D2CC02531K ISSN 1359-7345.
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WRAP-Minimalistic-ice-recrystallisation-inhibitors-based-on-phenylalanine-Gibson-22.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (3458Kb) | Preview |
Official URL: http://dx.doi.org/10.1039/D2CC02531K
Abstract
Ice recrystallisation inhibition (IRI) is typically associated with ice binding proteins, but polymers and other mimetics are emerging. Here we identify phenylalanine as a minimalistic, yet potent, small-molecule IRI capable of inhibiting ice growth at just 1 mg mLâ1. Facial amphiphilicity is shown to be a crucial structural feature, with para-substituents enhancing (hydrophobic) or decreasing (hydrophilic) IRI activity. Both amino and acid groups were found to be essential. Solution-phase self-assembly of Phenylalanine was not observed, but the role of self-assembly at the ice/water interface could not be ruled out as a contributing factor.
Item Type: | Journal Article | |||||||||||||||
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Subjects: | Q Science > QD Chemistry | |||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Science > Physics Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School Faculty of Science, Engineering and Medicine > Science > Chemistry > Computational and Theoretical Chemistry Centre |
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Library of Congress Subject Headings (LCSH): | Crystallization, Ice crystals -- Growth, Phenylalanine, Antifreeze proteins | |||||||||||||||
Journal or Publication Title: | Chemical Communications | |||||||||||||||
Publisher: | Royal Society of Chemistry | |||||||||||||||
ISSN: | 1359-7345 | |||||||||||||||
Official Date: | 14 July 2022 | |||||||||||||||
Dates: |
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Volume: | 58 | |||||||||||||||
Number: | 55 | |||||||||||||||
Number of Pages: | 4 | |||||||||||||||
Page Range: | pp. 7658-7661 | |||||||||||||||
DOI: | 10.1039/D2CC02531K | |||||||||||||||
Status: | Peer Reviewed | |||||||||||||||
Publication Status: | Published | |||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||
Date of first compliant deposit: | 21 June 2022 | |||||||||||||||
Date of first compliant Open Access: | 23 June 2022 | |||||||||||||||
RIOXX Funder/Project Grant: |
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