The Library
Adenosine is released during thalamic oscillations to provide negative feedback control
Tools
Tools
Tools
Wall, Mark J., Puddefoot, Katie, Yin, Wencheng, Bingham, Chris, Seifi, Mohsen, Swinny, Jerome D. and Teke Ngomba, Richard (2022) Adenosine is released during thalamic oscillations to provide negative feedback control. Neuropharmacology, 216 . 109172. doi:10.1016/j.neuropharm.2022.109172 ISSN 0028-3908.
|
PDF
WRAP-adenosine-thalamic-oscillations-negative-feedback-control-Wall-2022.pdf - Accepted Version - Requires a PDF viewer. Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. Download (2239Kb) | Preview |
Official URL: https://doi.org/10.1016/j.neuropharm.2022.109172
Abstract
Physiological oscillations in the cortico-thalamo-cortical loop occur during processes such as sleep, but these can become dysfunctional in pathological conditions such as absence epilepsy. The purine neuromodulator adenosine can act as an endogenous anticonvulsant: it is released into the extracellular space during convulsive seizures to activate A1 receptors suppressing on-going activity and delaying the occurrence of the next seizure. However, the role of adenosine in thalamic physiological and epileptiform oscillations is less clear. Here we have combined immunohistochemistry, electrophysiology, and fixed potential amperometry (FPA) biosensor measurements to characterise the release and actions of adenosine in thalamic oscillations measured in rodent slices. In the thalamus, A1 receptors are highly expressed particularly in the ventral basal (VB) thalamus and reticular thalamic nucleus (nRT) supporting a role for adenosine signalling in controlling oscillations. In agreement with previous studies, both adenosine and adenosine A1 receptor agonists inhibited thalamic oscillations in control (spindle-like) and in epileptic conditions. Here we have shown for the first time that both control and epileptiform oscillations are enhanced (i.e., increased number of oscillatory cycles) by blocking A1 receptors consistent with adenosine release occurring during oscillations. Although increases in extracellular adenosine could not be directly detected during control oscillations, clear increases in adenosine concentration could be detected with a biosensor during epileptiform oscillation activity. Thus, adenosine is released during thalamic oscillations and acts via A1 receptors to feedback and reduce thalamic oscillatory activity.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
| Library of Congress Subject Headings (LCSH): | Adenosine, Thalamus -- Physiology, Petit mal epilepsy -- Complications | ||||||||
| Journal or Publication Title: | Neuropharmacology | ||||||||
| Publisher: | Elsevier | ||||||||
| ISSN: | 0028-3908 | ||||||||
| Official Date: | 15 September 2022 | ||||||||
| Dates: |
|
||||||||
| Volume: | 216 | ||||||||
| Article Number: | 109172 | ||||||||
| DOI: | 10.1016/j.neuropharm.2022.109172 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| Date of first compliant deposit: | 27 June 2022 | ||||||||
| Date of first compliant Open Access: | 1 July 2023 | ||||||||
| RIOXX Funder/Project Grant: |
|
||||||||
| Related URLs: |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
