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Selective autophagy and Golgi quality control in Drosophila

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Gohel, Raksha, Rahman, Ashrafur, Lőrincz, Peter, Nagy, Anikó, Csordás, Gábor, Zhang, Yan, Juhász, Gábor and Nezis, Ioannis P. (2022) Selective autophagy and Golgi quality control in Drosophila. Autophagy, 18 (10). pp. 2508-2509. doi:10.1080/15548627.2022.2098765 ISSN 1554-8627.

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Official URL: https://doi.org/10.1080/15548627.2022.2098765

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Abstract

The LIR motif-docking site (LDS) of Atg8/LC3 proteins is essential for the binding of LC3-interacting region (LIR)-containing proteins and their subsequent degradation by macroautophagy/autophagy. In our recent study, we created a mutated LDS site in Atg8a, the Drosophila homolog of Atg8/LC3 and found that LDS mutants accumulate known autophagy substrates and have reduced lifespan. We also conducted quantitative proteomics analyses and identified several proteins that are enriched in the LDS mutants, including Gmap (Golgi microtubule-associated protein). Gmap contains a LIR motif and accumulates in LDS mutants. We showed that Gmap and Atg8a interact in a LIR-LDS dependent manner and that the Golgi size and morphology are altered in Atg8a-LDS and Gmap-LIR motif mutants. Our findings highlight a role for Gmap in the regulation of Golgiphagy.

Item Type: Journal Article
Subjects: Q Science > QH Natural history
Q Science > QP Physiology
Divisions: Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- )
Library of Congress Subject Headings (LCSH): Drosophila -- Physiology, Golgi apparatus, Cellular control mechanisms, Cell death, Protein-protein interactions
Journal or Publication Title: Autophagy
Publisher: Taylor & Francis
ISSN: 1554-8627
Official Date: 12 July 2022
Dates:
DateEvent
12 July 2022Published
1 July 2022Accepted
Volume: 18
Number: 10
Page Range: pp. 2508-2509
DOI: 10.1080/15548627.2022.2098765
Status: Peer Reviewed
Publication Status: Published
Reuse Statement (publisher, data, author rights): This is an Accepted Manuscript of an article published by Taylor & Francis in Autophagy on 12 July 2022, available online: http://www.tandfonline.com/10.1080/15548627.2022.2098765
Access rights to Published version: Restricted or Subscription Access
Date of first compliant deposit: 4 July 2022
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
BB/L006324/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
BB/P007856/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
BB/V014838/1[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
RPG-2017-023Leverhulme Trusthttp://dx.doi.org/10.13039/501100000275

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