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Selective autophagy and Golgi quality control in Drosophila
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Gohel, Raksha, Rahman, Ashrafur, Lőrincz, Peter, Nagy, Anikó, Csordás, Gábor, Zhang, Yan, Juhász, Gábor and Nezis, Ioannis P. (2022) Selective autophagy and Golgi quality control in Drosophila. Autophagy . doi:10.1080/15548627.2022.2098765 (In Press)
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WRAP-Selective-autophagy-Golgi-control-drosophila-2022.pdf - Accepted Version Embargoed item. Restricted access to Repository staff only until 12 July 2023. Contact author directly, specifying your specific needs. - Requires a PDF viewer. Download (341Kb) |
Official URL: https://doi.org/10.1080/15548627.2022.2098765
Abstract
The LIR motif-docking site (LDS) of Atg8/LC3 proteins is essential for the binding of LC3-interacting region (LIR)-containing proteins and their subsequent degradation by macroautophagy/autophagy. In our recent study, we created a mutated LDS site in Atg8a, the Drosophila homolog of Atg8/LC3 and found that LDS mutants accumulate known autophagy substrates and have reduced lifespan. We also conducted quantitative proteomics analyses and identified several proteins that are enriched in the LDS mutants, including Gmap (Golgi microtubule-associated protein). Gmap contains a LIR motif and accumulates in LDS mutants. We showed that Gmap and Atg8a interact in a LIR-LDS dependent manner and that the Golgi size and morphology are altered in Atg8a-LDS and Gmap-LIR motif mutants. Our findings highlight a role for Gmap in the regulation of Golgiphagy.
| Item Type: | Journal Article | |||||||||||||||
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| Subjects: | Q Science > QH Natural history Q Science > QP Physiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | |||||||||||||||
| Library of Congress Subject Headings (LCSH): | Drosophila -- Physiology, Golgi apparatus, Cellular control mechanisms, Cell death, Protein-protein interactions | |||||||||||||||
| Journal or Publication Title: | Autophagy | |||||||||||||||
| Publisher: | Taylor & Francis | |||||||||||||||
| ISSN: | 1554-8627 | |||||||||||||||
| Official Date: | 12 July 2022 | |||||||||||||||
| Dates: |
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| DOI: | 10.1080/15548627.2022.2098765 | |||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||
| Publication Status: | In Press | |||||||||||||||
| Reuse Statement (publisher, data, author rights): | This is an Accepted Manuscript of an article published by Taylor & Francis in Autophagy on 12 July 2022, available online: http://www.tandfonline.com/10.1080/15548627.2022.2098765 | |||||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | |||||||||||||||
| RIOXX Funder/Project Grant: |
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