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A novel multinuclear solid-state NMR approach for the characterization of kidney stones

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Leroy, César, Bonhomme-Coury, Laure, Gervais, Christel, Tielens, Frederik, Babonneau, Florence, Daudon, Michel, Bazin, Dominique, Letavernier, Emmanuel, Laurencin, Danielle, Iuga, Dinu, Hanna, John V., Smith, Mark E. and Bonhomme, Christian (2021) A novel multinuclear solid-state NMR approach for the characterization of kidney stones. Magnetic Resonance, 2 (2). pp. 653-671. doi:10.5194/mr-2-653-2021 ISSN 2699-0016.

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Official URL: http://dx.doi.org/10.5194/mr-2-653-2021

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Abstract

The spectroscopic study of pathological calcifications (including kidney stones) is extremely rich and helps to improve the understanding of the physical and chemical processes associated with their formation. While Fourier transform infrared (FTIR) imaging and optical/electron microscopies are routine techniques in hospitals, there has been a dearth of solid-state NMR studies introduced into this area of medical research, probably due to the scarcity of this analytical technique in hospital facilities. This work introduces effective multinuclear and multidimensional solid-state NMR methodologies to study the complex chemical and structural properties characterizing kidney stone composition. As a basis for comparison, three hydrates (n=1, 2 and 3) of calcium oxalate are examined along with nine representative kidney stones. The multinuclear magic angle spinning (MAS) NMR approach adopted investigates the 1H, 13C, 31P and 31P nuclei, with the 1H and 13C MAS NMR data able to be readily deconvoluted into the constituent elements associated with the different oxalates and organics present. For the first time, the full interpretation of highly resolved 1H NMR spectra is presented for the three hydrates, based on the structure and local dynamics. The corresponding 31P MAS NMR data indicates the presence of low-level inorganic phosphate species; however, the complexity of these data make the precise identification of the phases difficult to assign. This work provides physicians, urologists and nephrologists with additional avenues of spectroscopic investigation to interrogate this complex medical dilemma that requires real, multitechnique approaches to generate effective outcomes.

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
R Medicine > RC Internal medicine
Divisions: Faculty of Science, Engineering and Medicine > Science > Physics
Library of Congress Subject Headings (LCSH): Kidneys -- Calculi -- Treatment, Nuclear magnetic resonance spectroscopy, Inorganic compounds -- Analysis
Journal or Publication Title: Magnetic Resonance
Publisher: Copernicus Publications
ISSN: 2699-0016
Official Date: 20 August 2021
Dates:
DateEvent
20 August 2021Published
15 June 2021Accepted
Volume: 2
Number: 2
Page Range: pp. 653-671
DOI: 10.5194/mr-2-653-2021
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access (Creative Commons)
Date of first compliant deposit: 5 July 2022
Date of first compliant Open Access: 6 July 2022
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
097535Grand Équipement National De Calcul IntensifUNSPECIFIED
PR140003[EPSRC] Engineering and Physical Sciences Research Councilhttp://dx.doi.org/10.13039/501100000266
PR140003[BBSRC] Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
UNSPECIFIEDUniversity of Warwickhttp://dx.doi.org/10.13039/501100000741
UNSPECIFIEDBirmingham Science City Advanced MaterialsUNSPECIFIED
UNSPECIFIEDAdvantage West Midlandshttp://dx.doi.org/10.13039/100014381
UNSPECIFIED[ERDF] European Regional Development Fundhttp://dx.doi.org/10.13039/501100008530

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