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Elucidating the molecular mechanisms of selective autophagy in Drosophila melanogaster
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Rahman, Ashrafur (2021) Elucidating the molecular mechanisms of selective autophagy in Drosophila melanogaster. PhD thesis, University of Warwick.
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Official URL: http://webcat.warwick.ac.uk/record=b3781100
Abstract
Autophagy is an evolutionary conserved process of cellular self-degradation. It involves the lysosomal degradation of cellular materials, via an intermediate double membrane vesicle, where the degradation products can be reused by the cell. It is known that as well as bulk degradation autophagy can happen in a highly selective manner through receptors and adapters. One of the key players in this is the LC3 protein. This project investigates selective autophagy using Drosophila Melanogaster as a genetically modifiable organism. The Drosophila homologue of the mammalian LC3 proteins is ATG8a. ATG8a has a hydrophobic binding pocket (LDS) which binds autophagy substrates that contain a LC3 interacting region (LIR). Quantitative proteomics on Drosophila with a mutated LDS hydrophobic binding pocket was used to identify a panel of ATG8a interacting proteins. From this analysis, Drosophila GMAP (Golgi microtubule-associated protein) was discovered as a novel autophagy receptor. This study has shown that Drosophila GMAP has a role in golgiphagy, the selective degradation of the Golgi complex.
| Item Type: | Thesis (PhD) | ||||
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| Subjects: | Q Science > QH Natural history Q Science > QL Zoology Q Science > QP Physiology |
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| Library of Congress Subject Headings (LCSH): | Autophagic vacuoles, Biodegradation, Drosophila melanogaster, Proteomics | ||||
| Official Date: | September 2021 | ||||
| Dates: |
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| Institution: | University of Warwick | ||||
| Theses Department: | School of Life Sciences | ||||
| Thesis Type: | PhD | ||||
| Publication Status: | Unpublished | ||||
| Supervisor(s)/Advisor: | Nezis, Ioannis P. | ||||
| Format of File: | |||||
| Extent: | 200 leaves, 23 unnumbered leaves : colour illustrations | ||||
| Language: | eng |
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