Stranges, Saverio, Laclaustra, Martin, Ji, Chen, Cappuccio, Francesco P., Navas-Acien, Ana, Ordovas, J. M., Rayman, Margaret and Guallar, Eliseo. (2010) Higher selenium status is associated with adverse blood lipid profile in British adults. Journal of Nutrition, Vol.140 (No.1). pp. 81-87. ISSN 0022-3166

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Abstract

Recent findings have raised concern about possible associations of high selenium exposure with diabetes and hyperlipidemia in the US, a population with high selenium status. In the UK, a population with lower selenium status, there is little data on the association of selenium status with cardio-metabolic risk factors in the general population. We examined the association of plasma selenium concentration with blood lipids in a nationally representative sample of British adults. A cross-sectional study was conducted among 1042 white participants (aged 19-64 y) in the 2000-2001 UK National Diet and Nutrition Survey. Plasma selenium was measured by inductively coupled-plasma mass spectrometry. Total and HDL cholesterol were measured in nonfasting plasma samples. Mean plasma selenium concentration was 1.10 +/- 0.19 mu mol/L. The multivariate adjusted differences between the highest (>= 1.20 mu mol/L) and lowest (<0.98 mu mol/L) quartiles of plasma selenium were 0.39 (95% CI 0.18, 0.60) mmol/L for total cholesterol, 0.38 (0.17, 0.59) for non-HDL cholesterol, and 0.01 (-0.05, 0.07) for HDL cholesterol. Higher plasma selenium (i.e., >= 1.20 mu mol/L) was associated with increased total and non-HDL cholesterol levels but not with HDL in the UK adult population. These findings raise additional concern about potential adverse cardio-metabolic effects of high selenium status. Randomized and mechanistic evidence is necessary to assess causality and to evaluate the impact of this association on cardiovascular risk. J. Nutr. 140: 81-87, 2010.

Item Type:	Journal Article
Subjects:	R Medicine > RA Public aspects of medicine
Divisions:	Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School > Metabolic and Vascular Health Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	Journal of Nutrition
Publisher:	American Society for Nutrition
ISSN:	0022-3166
Date:	January 2010
Volume:	Vol.140
Number:	No.1
Number of Pages:	7
Page Range:	pp. 81-87
Identification Number:	10.3945/​jn.109.111252
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	National Institute of Environmental Health Sciences (NIEHS), American Heart Association (AHA), UK National Diet and Nutrition Survey, Great Britain. Food Standards Agency (FSA), Great Britain. Dept. of Health (DoH), Great Britain. Office for National Statistics (ONS), Medical Research Council (Great Britain) (MRC)
Grant number:	1 R01 ES012673 (NIEHS), 0230232N (AHA)
URI:	http://wrap.warwick.ac.uk/id/eprint/16717

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