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Perioperative oxygen therapy : a protocol for an overview of systematic reviews and meta-analyses
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Elfeky, Adel, Chen, Yen-Fu, Grove, Amy L., Hooper, Amy, Wilson, Anna, Couper, Keith, Thompson, Marion, Uthman, Olalekan A., Court, Rachel A., Tomassini, Sara and Yeung, Joyce (2022) Perioperative oxygen therapy : a protocol for an overview of systematic reviews and meta-analyses. Systematic Reviews, 11 (1). 140. doi:10.1186/s13643-022-02005-3 ISSN 2046-4053.
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WRAP-perioperative-oxygen-therapy-protocol-overview-systematic-reviews-and-meta-analyses-2022.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1260Kb) | Preview |
Official URL: https://doi.org/10.1186/s13643-022-02005-3
Abstract
Background: Oxygen is routinely given to patients during and after surgery. Perioperative oxygen administration has been proposed as a potential strategy to prevent and treat hypoxaemia and reduce complications, such as surgical site infections, pulmonary complications and mortality. However, uncertainty exists as to which strategies in terms of amount, delivery devices and timing are clinically effective. The aim of this overview of systematic reviews and meta-analyses is to answer the research question, βFor which types of surgery, at which stages of care, in which sub-groups of patients and delivered under what conditions are different types of perioperative oxygen therapy clinically effective?β. Methods: We will search key electronic databases (MEDLINE, EMBASE, the Cochrane Database of Systematic Reviews, CENTRAL, Epistemonikos, PROSPERO, the INAHTA International HTA Database and DARE archives) for systematic reviews and randomised controlled trials comparing perioperative oxygen strategies. Each review will be mapped according to type of surgery, surgical pathway timepoints and clinical comparison. The highest quality reviews with the most comprehensive and up-to-date coverage of relevant literature will be chosen as anchoring reviews. Standardised data will be extracted from each chosen review, including definition of oxygen therapy, summaries of interventions and comparators, patient population, surgical characteristics and assessment of overall certainty of evidence. For clinical outcomes and adverse events, the overall pooled findings and results of subgroup and sensitivity analyses (where available) will be extracted. Trial-level data will be extracted for surgical site infections, mortality, and potential trial-level effect modifiers such as risk of bias, outcome definition and type of surgery to facilitate quantitative data analysis. This analysis will adopt a multiple indication review approach with panoramic meta-analysis using review-level data and meta-regression using trial-level data. An evidence map will be produced to summarise our findings and highlight any research gaps. Discussion: There is a need to provide a panoramic overview of systematic reviews and meta-analyses describing peri-operative oxygen practice to both inform clinical practice and identify areas of ongoing uncertainty, where further research may be required. Systematic review registration: PROSPERO CRD42021272361
| Item Type: | Journal Article | |||||||||||||||
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| Subjects: | R Medicine > RB Pathology R Medicine > RC Internal medicine R Medicine > RM Therapeutics. Pharmacology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| SWORD Depositor: | Library Publications Router | |||||||||||||||
| Library of Congress Subject Headings (LCSH): | Oxygen therapy , Oxygen -- Physiological transport , Anoxemia -- Prevention | |||||||||||||||
| Journal or Publication Title: | Systematic Reviews | |||||||||||||||
| Publisher: | BioMed Central Ltd. | |||||||||||||||
| ISSN: | 2046-4053 | |||||||||||||||
| Official Date: | 12 July 2022 | |||||||||||||||
| Dates: |
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| Volume: | 11 | |||||||||||||||
| Number: | 1 | |||||||||||||||
| Article Number: | 140 | |||||||||||||||
| DOI: | 10.1186/s13643-022-02005-3 | |||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||
| Publication Status: | Published | |||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||
| Date of first compliant deposit: | 22 July 2022 | |||||||||||||||
| Date of first compliant Open Access: | 22 July 2022 | |||||||||||||||
| RIOXX Funder/Project Grant: |
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