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Economic costs and health utility values associated with extremely preterm birth : evidence from the EPICure2 cohort study
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Achana, Felix A., Johnson, Samantha, Ni, Yanyan, Marlow, Neil, Wolke, Dieter, Khan, Kamran and Petrou, Stavros (2022) Economic costs and health utility values associated with extremely preterm birth : evidence from the EPICure2 cohort study. Paediatric and Perinatal Epidemiology, 36 (5). pp. 696-705. doi:10.1111/ppe.12906 ISSN 1365-3016.
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WRAP-economic-costs-health-utility-values-associated-with-extremely-preterm-birth-evidence-from-EPICure2-cohort-study-2022.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (345Kb) | Preview |
Official URL: https://doi.org/10.1111/ppe.12906
Abstract
Background
Preterm birth is associated with adverse health and developmental sequelae that impose a burden on finite resources and significant challenges for individuals, families and societies.
Objectives
To estimate economic outcomes at age 11 associated with extremely preterm birth using evidence from a whole population study (EPICure2 study).
Methods
The study population comprised a sample of children born at ≤26 completed weeks of gestation during 2006 in England (n = 200) and a comparison group of classmates born at term (n = 143). Societal costs were estimated using parent and teacher reports of service utilisation, and valuations of work losses and additional care costs to families. Utility scores for the Health Utilities Index Mark 2 (HUI2) and Mark 3 (HUI3) were generated using UK and Canadian value sets. Generalised linear regression was used to estimate the impact of extremely preterm birth on societal costs and utility scores.
Results
Unadjusted mean societal costs that excluded provision of special educational support in mainstream schools during the 11th year after birth were £6536 for the extremely preterm group and £3275 for their classmates, generating a difference of £3262 (95% confidence interval [CI] £1912, £5543). The mean adjusted cost difference was £2916 (95% CI £1609, £4224), including special educational needs provision in mainstream schools increased the adjusted cost difference to £4772 (95% CI £3166, £6378). Compared with birth at term, extremely preterm birth generated mean-adjusted utility decrements ranging from 0.13 (95% CI 0.09, 0.18) based on the UK HUI2 statistical inference tariff to 0.28 (95% CI 0.18, 0.37) based on the Canadian HUI3 tariff.
Conclusions
The adverse economic impact of extremely preterm birth persists into late childhood. Further longitudinal studies conducted from multiple perspectives are needed to understand the magnitude, trajectory and underpinning mechanisms of economic outcomes following extremely preterm birth.
| Item Type: | Journal Article | |||||||||
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| Subjects: | R Medicine > RG Gynecology and obstetrics R Medicine > RJ Pediatrics |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Psychology | |||||||||
| SWORD Depositor: | Library Publications Router | |||||||||
| Library of Congress Subject Headings (LCSH): | Premature labor , Premature labor -- United States, Labor (Obstetrics) -- Complications, Premature infants -- Medical care -- Economic aspects, Premature infants -- Care -- Economic aspects | |||||||||
| Journal or Publication Title: | Paediatric and Perinatal Epidemiology | |||||||||
| Publisher: | Wiley | |||||||||
| ISSN: | 1365-3016 | |||||||||
| Official Date: | September 2022 | |||||||||
| Dates: |
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| Volume: | 36 | |||||||||
| Number: | 5 | |||||||||
| Page Range: | pp. 696-705 | |||||||||
| DOI: | 10.1111/ppe.12906 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||
| Date of first compliant deposit: | 14 July 2022 | |||||||||
| Date of first compliant Open Access: | 15 July 2022 | |||||||||
| RIOXX Funder/Project Grant: |
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