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Bio-Inspired degradable polyethylenimine/calcium phosphate micro-/nano composites for transient ultrasound and photoluminescence imaging
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Held, T., Bradley, D. G., Xue, M., Ko, S. T., Qi, B., Li, Y., Cheng, Y., Jin, Z., Zhou, J., Sasi, L., Fuentes, L. J., Wu, Z., Zhou, J., Yim, W., Chang, Y. C., Hanna, John V., Luo, J. and Jokerst, J. V. (2022) Bio-Inspired degradable polyethylenimine/calcium phosphate micro-/nano composites for transient ultrasound and photoluminescence imaging. Chemistry of Materials, 34 (16). pp. 7220-7231. doi:10.1021/acs.chemmater.2c00857 ISSN 0897-4756.
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WRAP-bio-inspired-degradable-polyethylenimine-calcium-phosphate-micro-nano-composites-transient-ultrasound-photoluminescence-imaging-Hanna-2022.pdf - Accepted Version - Requires a PDF viewer. Download (1740Kb) | Preview |
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WRAP-Bio-Inspired-degradable-polyethylenimine-calcium-phosphate-micro-nano-composites-transient-ultrasound-photoluminescene-supporting-information-2022.pdf - Supplemental Material Embargoed item. Restricted access to Repository staff only - Requires a PDF viewer. Download (11Mb) |
Official URL: https://doi.org/10.1021/acs.chemmater.2c00857
Abstract
Inorganic nanomaterials hold immense potential in theranostics, but their translation is limited by the toxicity resulting from non-degradability. Bulk phosphate-based glasses offer great biodegradability, biocompatibility, and ease in incorporating imaging dyes and drugs. However, the facile and mild solution-based synthesis of micro-/nanoparticles of this material is yet to be explored. Inspired by the biosilicification process in the diatom, we created polyethylenimine (PEI)/phosphate aggregates via the hydrogen bonding between amine (PEI) and hydroxyl (phosphate) groups, which was proved by dynamic light scattering and 1H solution nuclear magnetic resonance. The sol–gel reaction between the calcium precursor and PEI/phosphate aggregates yielded degradable PEI/calcium phosphate (PEI/CP) micro-/nano-composites with versatile sizes (396 ± 128 nm to 63 ± 8 μm) and morphologies (hexagonal micro-disc, micro-flower, micro-leaf, nano-butterfly, and nano-ribbon). The PEI/CP composition and chemical structure were examined. PEI/CP has negligible cell cytotoxicity and degrades within 24 h. In vitro studies showed the promise for PEI/CP in transient ultrasound and photoluminescence imaging.
| Item Type: | Journal Article | |||||||||||||||||||||||||||||||||
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| Subjects: | Q Science > QC Physics Q Science > QD Chemistry T Technology > TD Environmental technology. Sanitary engineering |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Physics | |||||||||||||||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Biodegradation, Calcium phosphate -- Biotechnology, Nanostructured materials -- Biodegradation., Photoluminescence, Biomedical materials, Biomedical engineering | |||||||||||||||||||||||||||||||||
| Journal or Publication Title: | Chemistry of Materials | |||||||||||||||||||||||||||||||||
| Publisher: | American Chemical Society | |||||||||||||||||||||||||||||||||
| ISSN: | 0897-4756 | |||||||||||||||||||||||||||||||||
| Official Date: | 23 August 2022 | |||||||||||||||||||||||||||||||||
| Dates: |
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| Volume: | 34 | |||||||||||||||||||||||||||||||||
| Number: | 16 | |||||||||||||||||||||||||||||||||
| Page Range: | pp. 7220-7231 | |||||||||||||||||||||||||||||||||
| DOI: | 10.1021/acs.chemmater.2c00857 | |||||||||||||||||||||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||||||||||||||||||||
| Publication Status: | Published | |||||||||||||||||||||||||||||||||
| Reuse Statement (publisher, data, author rights): | This document is the Accepted Manuscript version of a Published Work that appeared in final form in Chemistry of Materials, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see ACS Articles on Request. | |||||||||||||||||||||||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | |||||||||||||||||||||||||||||||||
| Copyright Holders: | © 2022 American Chemical Society | |||||||||||||||||||||||||||||||||
| Date of first compliant deposit: | 15 July 2022 | |||||||||||||||||||||||||||||||||
| Date of first compliant Open Access: | 5 August 2023 | |||||||||||||||||||||||||||||||||
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