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Transmission history of SARS-CoV-2 in humans and white-tailed deer
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Willgert, Katriina, Didelot, Xavier, Surendran-Nair, Meera, Kuchipudi, Suresh V., Ruden, Rachel M., Yon, Michele, Nissly, Ruth H., Vandegrift, Kurt J., Nelli, Rahul K., Li, Lingling, Jayarao, Bhushan M., Levine, Nicole, Olsen, Randall J., Davis, James J., Musser, James M., Hudson, Peter J., Kapur, Vivek and Conlan, Andrew J. K. (2022) Transmission history of SARS-CoV-2 in humans and white-tailed deer. Scientific Reports, 12 (1). 12094. doi:10.1038/s41598-022-16071-z ISSN 2045-2322. [ 🗎 Public]. [ (✓) hoa:511 ]
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41598_2022_Article_16071.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (2724Kb) | Preview |
Official URL: https://doi.org/10.1038/s41598-022-16071-z
Abstract
Abstract: The emergence of a novel pathogen in a susceptible population can cause rapid spread of infection. High prevalence of SARS-CoV-2 infection in white-tailed deer (Odocoileus virginianus) has been reported in multiple locations, likely resulting from several human-to-deer spillover events followed by deer-to-deer transmission. Knowledge of the risk and direction of SARS-CoV-2 transmission between humans and potential reservoir hosts is essential for effective disease control and prioritisation of interventions. Using genomic data, we reconstruct the transmission history of SARS-CoV-2 in humans and deer, estimate the case finding rate and attempt to infer relative rates of transmission between species. We found no evidence of direct or indirect transmission from deer to human. However, with an estimated case finding rate of only 4.2%, spillback to humans cannot be ruled out. The extensive transmission of SARS-CoV-2 within deer populations and the large number of unsampled cases highlights the need for active surveillance at the human–animal interface.
| Item Type: | Journal Article | ||||||||||||||||||||||||
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| Subjects: | Q Science > QL Zoology R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||||||||||||||||||
| SWORD Depositor: | Library Publications Router | ||||||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | COVID-19 (Disease), COVID-19 (Disease) -- Transmission, White-tailed deer , Veterinary virology, Virus diseases -- Transmission | ||||||||||||||||||||||||
| Journal or Publication Title: | Scientific Reports | ||||||||||||||||||||||||
| Publisher: | Nature Publishing Group | ||||||||||||||||||||||||
| ISSN: | 2045-2322 | ||||||||||||||||||||||||
| Official Date: | 2022 | ||||||||||||||||||||||||
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| Volume: | 12 | ||||||||||||||||||||||||
| Number: | 1 | ||||||||||||||||||||||||
| Article Number: | 12094 | ||||||||||||||||||||||||
| DOI: | 10.1038/s41598-022-16071-z | ||||||||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||||||||
| Publication Status: | Published | ||||||||||||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||||||||
| Date of first compliant deposit: | 19 July 2022 | ||||||||||||||||||||||||
| Date of first compliant Open Access: | 26 July 2022 | ||||||||||||||||||||||||
| RIOXX Funder/Project Grant: |
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