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Membrane lipid renovation in Pseudomonas aeruginosa ‐ implications for phage therapy?
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Lyon, Rhiannon, Jones, Rebekah A., Shropshire, Holly, Aberdeen, Isabel, Scanlan, David J., Millard, Andrew and Chen, Yin (2022) Membrane lipid renovation in Pseudomonas aeruginosa ‐ implications for phage therapy? Environmental Microbiology, 24 (10). pp. 4533-4546. doi:10.1111/1462-2920.16136 ISSN 1462-2912.
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WRAP-membrane-lipid-renovation-Pseudomonas-aeruginosa‐implications-phage-therapy-2022.pdf - Accepted Version Embargoed item. Restricted access to Repository staff only until 15 July 2023. Contact author directly, specifying your specific needs. - Requires a PDF viewer. Download (1554Kb) |
Official URL: http://dx.doi.org/10.1111/1462-2920.16136
Abstract
Pseudomonas aeruginosa is an important Gram-negative pathogen with intrinsic resistance to many clinically used antibiotics. It is particularly troublesome in nosocomial infections, immunocompromised patients, and individuals with cystic fibrosis. Antimicrobial resistance (AMR) is a huge threat to global health, with a predicted 10 million people dying from resistant infections by 2050. A promising therapy for combatting AMR infections is phage therapy. However, more research is required to investigate mechanisms that may influence the efficacy of phage therapy. An important overlooked aspect is the impact of membrane lipid remodelling on phage binding ability. P. aeruginosa undergoes changes in membrane lipids when it encounters phosphorus stress, an environmental perturbation that is likely to occur during infection. Lipid changes include the substitution of glycerophospholipids with surrogate glycolipids and the over-production of ornithine-containing aminolipids. Given that membrane lipids are known to influence the structure and function of membrane proteins, we propose that changes in the composition of membrane lipids during infection may alter phage binding and subsequent phage infection dynamics. Consideration of such effects needs to be urgently prioritised in order to develop the most effective phage therapy strategies for P. aeruginosa infections.
| Item Type: | Journal Article | |||||||||
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| Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | |||||||||
| Library of Congress Subject Headings (LCSH): | Pseudomonas aeruginosa, Membrane lipids, Bacteriophages -- Therapeutic use | |||||||||
| Journal or Publication Title: | Environmental Microbiology | |||||||||
| Publisher: | Blackwell | |||||||||
| ISSN: | 1462-2912 | |||||||||
| Official Date: | October 2022 | |||||||||
| Dates: |
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| Volume: | 24 | |||||||||
| Number: | 10 | |||||||||
| Page Range: | pp. 4533-4546 | |||||||||
| DOI: | 10.1111/1462-2920.16136 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Reuse Statement (publisher, data, author rights): | This is the peer reviewed version of the following article: Lyon, R., Jones, R.A., Shropshire, H., Aberdeen, I., Scanlan, D.J., Millard, A. and Chen, Y. (2022), Membrane lipid renovation in Pseudomonas aeruginosa - implications for phage therapy?. Environ Microbiol., which has been published in final form at https://doi.org/10.1111/1462-2920.16136. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. | |||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||
| Date of first compliant deposit: | 19 July 2022 | |||||||||
| RIOXX Funder/Project Grant: |
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