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Glycosylated gold nanoparticles in point of care diagnostics : from aggregation to lateral flow
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Baker, Alexander N., Hawker-Bond, George W., Georgiou, Panagiotis G., Dedola, Simone, Field, Robert A. and Gibson, Matthew I. (2022) Glycosylated gold nanoparticles in point of care diagnostics : from aggregation to lateral flow. Chemical Society Reviews, 51 (16). pp. 7238-7259. doi:10.1039/D2CS00267A ISSN 0306-0012.
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WRAP-Glycosylated-gold-nanoparticles-point-care-diagnostics-aggregation-lateral-flow-2022.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution. Download (3237Kb) | Preview |
Official URL: http://dx.doi.org/10.1039/D2CS00267A
Abstract
Current point-of-care lateral flow immunoassays, such as the home pregnancy test, rely on proteins as detection units (e.g. antibodies) to sense for analytes. Glycans play a fundamental role in biological signalling and recognition events such as pathogen adhesion and hence they are promising future alternatives to antibody-based biosensing and diagnostics. Here we introduce the potential of glycans coupled to gold nanoparticles as recognition agents for lateral flow diagnostics. We first introduce the concept of lateral flow, including a case study of lateral flow use in the field compared to other diagnostic tools. We then introduce glycosylated materials, the affinity gains achieved by the cluster glycoside effect and the current use of these in aggregation based assays. Finally, the potential role of glycans in lateral flow are explained, and examples of their successful use given.
| Item Type: | Journal Article | |||||||||||||||
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| Subjects: | Q Science > QD Chemistry R Medicine > RC Internal medicine |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Point-of-care testing, Immunoassay, Nanoparticles, Gold, Oligosaccharides | |||||||||||||||
| Journal or Publication Title: | Chemical Society Reviews | |||||||||||||||
| Publisher: | Royal Society of Chemistry | |||||||||||||||
| ISSN: | 0306-0012 | |||||||||||||||
| Official Date: | 21 August 2022 | |||||||||||||||
| Dates: |
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| Volume: | 51 | |||||||||||||||
| Number: | 16 | |||||||||||||||
| Page Range: | pp. 7238-7259 | |||||||||||||||
| DOI: | 10.1039/D2CS00267A | |||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||
| Publication Status: | Published | |||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||
| Date of first compliant deposit: | 28 July 2022 | |||||||||||||||
| Date of first compliant Open Access: | 29 July 2022 | |||||||||||||||
| RIOXX Funder/Project Grant: |
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