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Sleep disturbances and risk for psychosis
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Clarke, Latoya (2021) Sleep disturbances and risk for psychosis. PhD thesis, University of Warwick.
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Official URL: http://webcat.warwick.ac.uk/record=b3782393~S15
Abstract
There is increasing evidence showing an association between sleep disturbances and Psychotic Experiences (PE) in clinical and non-clinical groups. However, important research questions remain relating to (i) which specific sleep disturbances are associated with PE cross-sectionally and longitudinally (ii) the prospective relationship between sleep problems in childhood and PE in adulthood and (iii) how sleep disturbances are associated with PE and other key outcomes in at risk for psychosis groups.
Chapter 3 of this thesis presents a systematic review examining the cross-sectional and longitudinal relationship between sleep disturbances and PE across at risk for psychosis groups. Chapter 4 investigates the prospective association between childhood and adolescent sleep disturbances and PE in adulthood. Chapter 5 examines sleep disturbances and associated PE, functioning and Quality of Life (QoL) in an Australian and UK help seeking sample. The findings are integrated in Chapter 6 through the outline of an interventional study to be carried forward as part of the next steps.
Findings from Chapter 3 show that self-reported and objectively assessed sleep disturbances are associated with PE. However there is a dearth of evidence examining the relationship between sleep disturbances and QoL, and limited longitudinal research in this area. In Chapter 4, difficulties initiating and maintaining sleep, in addition to parasomnias during childhood and adolescence are found to be associated with the occurrence and persistence of PE at 24 years old. Chapter 5 reports a significant association between daytime sleepiness, chronotype and positive psychotic symptoms, functioning and QoL across a 12 month period.
This thesis presents compelling evidence to suggest that the relationship between sleep disturbances and PE is maintained over time and populations. Furthermore, there is some specificity in relation to which types of sleep problems relate to increased PE and therefore increased risk for psychosis. Chapter 6 presents the findings from a patient and public involvement study which explores methodological considerations for future studies seeking to understand the potential causal pathways underlying these co-occuring experiences across the psychosis continuum.
Item Type: | Thesis (PhD) | ||||
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Subjects: | B Philosophy. Psychology. Religion > BF Psychology R Medicine > RA Public aspects of medicine |
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Library of Congress Subject Headings (LCSH): | Sleep -- Psychological aspects, Sleep disorders, Psychoses -- Risk factors, Psychoses -- Diagnosis | ||||
Official Date: | August 2021 | ||||
Dates: |
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Institution: | University of Warwick | ||||
Theses Department: | Warwick Medical School | ||||
Thesis Type: | PhD | ||||
Publication Status: | Unpublished | ||||
Supervisor(s)/Advisor: | Thompson, Andrew D. ; Cappuccio, Francesco ; Chisholm, Kate ; Tang, Nicole K. Y. | ||||
Sponsors: | Economic and Social Research Council (Great Britain) | ||||
Extent: | 166 leaves : illustrations, charts | ||||
Language: | eng |
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