The Library
Visfatin/PBEF and atherosclerosis-related diseases
Tools
Filippatos, Theodosios D., Randeva, Harpal S., Derdemezis, Christos S., Elisaf, Moses S. and Mikhailidis, Dimitri P. (2010) Visfatin/PBEF and atherosclerosis-related diseases. Current Vascular Pharmacology, Vol.8 (No.1). pp. 12-28. doi:10.2174/157016110790226679
Research output not available from this repository.
Request-a-Copy directly from author or use local Library Get it For Me service.
Official URL: http://dx.doi.org/10.2174/157016110790226679
Abstract
Visfatin is highly expressed in adipose tissue (mainly by the stromal cells), but it is also ubiquitously present in most tissues. Visfatin, which plays a role in nicotinamide adenine dinucleotide (NAD) biosynthesis, has been implicated in inflammatory states.
Controversial results exist about the expression, circulating levels and the role of visfatin in atherosclerosis-related diseases. Most studies showed increased levels of visfatin in diabetes mellitus, obesity, hypertension, renal and cardiovascular disease. However, other studies reported lower levels of visfatin in these diseases. The discrepancies in clinical studies may be attributed to the multifactorial regulation of visfatin. There is evidence that visfatin expression and circulating levels are influenced by fat area and distribution, inflammatory state, renal function, iron metabolism, hormones as well as several other factors. Furthermore, discrepancies and lack of correlation between commercially available visfatin assays have been reported. More research is needed to better understand the factors that control its synthesis/release and to evaluate the role of visfatin in atherosclerosis-related disease. Large studies with homogeneous populations will probably be needed to answer these questions. Whether visfatin will eventually become a therapeutic target remains to be established.
Item Type: | Journal Item | ||||
---|---|---|---|---|---|
Subjects: | R Medicine > RS Pharmacy and materia medica R Medicine > RC Internal medicine |
||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
||||
Journal or Publication Title: | Current Vascular Pharmacology | ||||
Publisher: | Bentham Science Publishers Ltd. | ||||
ISSN: | 1570-1611 | ||||
Official Date: | January 2010 | ||||
Dates: |
|
||||
Volume: | Vol.8 | ||||
Number: | No.1 | ||||
Number of Pages: | 17 | ||||
Page Range: | pp. 12-28 | ||||
DOI: | 10.2174/157016110790226679 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access |
Data sourced from Thomson Reuters' Web of Knowledge
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |