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Imaging of antitubercular dimeric boronic acids at the mycobacterial cell surface by click-probe capture
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Guy, Collette S., Tomás, Ruben M. F., Tang, Qiao, Gibson, Matthew I. and Fullam, Elizabeth (2022) Imaging of antitubercular dimeric boronic acids at the mycobacterial cell surface by click-probe capture. Chemical Communications, 58 (67). pp. 9361-9364. doi:10.1039/D2CC02407A ISSN 1359-7345.
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WRAP-Imaging-of-antitubercular-dimeric-boronic-acids-at-the-mycobacterial-cell-surface-by-click-probe-capture-Fullam-22.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1670Kb) | Preview |
Official URL: http://dx.doi.org/10.1039/D2CC02407A
Abstract
Dimeric boronic acids kill Mycobacterium tuberculosis (Mtb) by targeting mycobacterial specific extracellular glycans, removing the requirement for a therapeutic agent to permeate the complex cell envelope. Here we report the successful development and use of new ‘clickable’ boronic acid probes as a powerful method to enable the direct detection and visualisation of this unique class of cell-surface targeting antitubercular agents.
Item Type: | Journal Article | ||||||||||||||||||
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Subjects: | Q Science > QD Chemistry Q Science > QR Microbiology |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Science > Chemistry Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Boron, Organic acids, Mycobacterium tuberculosis, Tuberculosis, Chemistry, Organic | ||||||||||||||||||
Journal or Publication Title: | Chemical Communications | ||||||||||||||||||
Publisher: | Royal Society of Chemistry | ||||||||||||||||||
ISSN: | 1359-7345 | ||||||||||||||||||
Official Date: | 2022 | ||||||||||||||||||
Dates: |
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Volume: | 58 | ||||||||||||||||||
Number: | 67 | ||||||||||||||||||
Page Range: | pp. 9361-9364 | ||||||||||||||||||
DOI: | 10.1039/D2CC02407A | ||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||||||||
Date of first compliant deposit: | 3 August 2022 | ||||||||||||||||||
Date of first compliant Open Access: | 8 August 2022 | ||||||||||||||||||
RIOXX Funder/Project Grant: |
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