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Preparation and characterization of polyethylenimine-coated Fe3O4-MCM-48 nanocomposite particles as a novel agent for magnet-assisted transfection
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Yiu, Humphrey H. P., McBain, Stuart C., Lethbridge, Zoe A. D., Lees, Martin R. and Dobson, Jon. (2010) Preparation and characterization of polyethylenimine-coated Fe3O4-MCM-48 nanocomposite particles as a novel agent for magnet-assisted transfection. Journal of Biomedical Materials Research Part A, Vol.92A (No.1). pp. 386-392. ISSN 1549-3296
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Official URL: http://dx.doi.org/10.1002/jbm.a.32363
Abstract
A new type of magnetic nanoparticle was synthesized using mesoporous silica MCM-48 as a template. Magnetite (Fe3O4) nanocrystals were incorporated onto the MCM-48 silica structure by thermal decomposition of iron(Ill) acetylacetonate. The particle size of these Fe3O4-MCM-48 composite particles is around 300 nm with an iron oxide content of ca. 20% w/w. Measurements from SQUID magnetometry suggest that these nanoparticles possess superparamagnetic properties similar to those of Fe3O4 nanoparticles. By coating positively charged polyethylenimine on to the surface, DNA can be bound onto the Fe3O4-MCM-48 nanoparticles. Transfection studies showed that these PEI-Fe3O4-MCM-48 particles were highly effective as a transfection reagent, and a 400% increase of transfection efficiency compared with the commercial products was recorded. (C) 2009 Wiley Periodicals, Inc. J Biomed Mater Res 92A: 386-392, 2010
| Item Type: | Journal Article |
|---|---|
| Subjects: | R Medicine |
| Divisions: | Faculty of Science > Chemistry Faculty of Science > Physics |
| Journal or Publication Title: | Journal of Biomedical Materials Research Part A |
| Publisher: | John Wiley & Sons Ltd. |
| ISSN: | 1549-3296 |
| Date: | January 2010 |
| Volume: | Vol.92A |
| Number: | No.1 |
| Number of Pages: | 7 |
| Page Range: | pp. 386-392 |
| Identification Number: | 10.1002/jbm.a.32363 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| Funder: | Royal Society (Great Britain), Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), UK Cystic Fibrosis Trust, Royal Society Wolfson Research Merit Award |
| Grant number: | BBS/B/14523 (BBSRC) |
| URI: | http://wrap.warwick.ac.uk/id/eprint/16802 |
Data sourced from Thomson Reuters' Web of Knowledge
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