Crossley, Nicolas A., Mechelli, Andrea, Fusar-Poli, Paolo, Broome, Matthew R., Matthiasson, Pall, Johns, Louise C., Bramon, Elvira, Valmaggia, Lucia, Williams, Steven C. R. and McGuire, Philip. (2009) Superior temporal lobe dysfunction and frontotemporal dysconnectivity in subjects at risk of psychosis and in first-episode psychosis. Human Brain Mapping, Vol.30 (No.12). pp. 4129-4137. ISSN 1065-9471

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Abstract

Background: Superior temporal lobe dysfunction is a robust finding in functional neuroimaging studies of schizophrenia and is thought to be related to a disruption of fronto-temporal functional connectivity. However, the stage of the disorder at which these functional alterations Occur is unclear. We addressed this issue by using functional MRI (fMRI) to Study Subjects in the prodromal and first episode phases of schizophrenia. Methods: Subjects with an at risk mental state (ARMS) for psychosis, a first psychotic episode (FEP), and controls were studied using fMRI while performing a working memory task. Activation in the Superior temporal gyrus (STG) was assessed using statistical parametric mapping, and its relationship to frontal activation was examined using dynamic causal modeling. Results: The STG was differentially engaged across the three groups. There was deactivation of this region during the task in controls, whereas Subjects with FEP showed activation and the response in subjects with ARMS was intermediately relative to the two other groups. There were corresponding differences in the effective connectivity between the STG and the middle frontal gyrus across the three groups, with a negative coupling between these areas in controls, a positive coupling in the FEP group, and an intermediate value in the ARMS group. Conclusions: A failure to deactivate the superior temporal lobe during tasks that engage prefrontal cortex is evident at the onset of schizophrenia and may reflect a disruption of fronto-temporal connectivity. Qualitatively similar alterations are evident in people with prodromal symptoms of the disorder. Hum Brain Mapp 30:4129-4137, 2009. (C) 2009 Wiley-Liss, Inc.

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine
Divisions:	Faculty of Medicine > Warwick Medical School > Mental Health and Wellbeing Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	Human Brain Mapping
Publisher:	John Wiley and Sons
ISSN:	1065-9471
Date:	December 2009
Volume:	Vol.30
Number:	No.12
Number of Pages:	9
Page Range:	pp. 4129-4137
Identification Number:	10.1002/hbm.20834
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	National Institute of Health Research, UK, Wellcome Trust, Department of Health, UK
URI:	http://wrap.warwick.ac.uk/id/eprint/16807

Data sourced from Thomson Reuters' Web of Knowledge

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