Superior temporal lobe dysfunction and frontotemporal dysconnectivity in subjects at risk of psychosis and in first-episode psychosis
Crossley, Nicolas A., Mechelli, Andrea, Fusar-Poli, Paolo, Broome, Matthew R., Matthiasson, Pall, Johns, Louise C., Bramon, Elvira, Valmaggia, Lucia, Williams, Steven C. R. and McGuire, Philip. (2009) Superior temporal lobe dysfunction and frontotemporal dysconnectivity in subjects at risk of psychosis and in first-episode psychosis. Human Brain Mapping, Vol.30 (No.12). pp. 4129-4137. ISSN 1065-9471Full text not available from this repository.
Official URL: http://dx.doi.org/10.1002/hbm.20834
Background: Superior temporal lobe dysfunction is a robust finding in functional neuroimaging studies of schizophrenia and is thought to be related to a disruption of fronto-temporal functional connectivity. However, the stage of the disorder at which these functional alterations Occur is unclear. We addressed this issue by using functional MRI (fMRI) to Study Subjects in the prodromal and first episode phases of schizophrenia. Methods: Subjects with an at risk mental state (ARMS) for psychosis, a first psychotic episode (FEP), and controls were studied using fMRI while performing a working memory task. Activation in the Superior temporal gyrus (STG) was assessed using statistical parametric mapping, and its relationship to frontal activation was examined using dynamic causal modeling. Results: The STG was differentially engaged across the three groups. There was deactivation of this region during the task in controls, whereas Subjects with FEP showed activation and the response in subjects with ARMS was intermediately relative to the two other groups. There were corresponding differences in the effective connectivity between the STG and the middle frontal gyrus across the three groups, with a negative coupling between these areas in controls, a positive coupling in the FEP group, and an intermediate value in the ARMS group. Conclusions: A failure to deactivate the superior temporal lobe during tasks that engage prefrontal cortex is evident at the onset of schizophrenia and may reflect a disruption of fronto-temporal connectivity. Qualitatively similar alterations are evident in people with prodromal symptoms of the disorder. Hum Brain Mapp 30:4129-4137, 2009. (C) 2009 Wiley-Liss, Inc.
|Item Type:||Journal Article|
|Subjects:||R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
|Divisions:||Faculty of Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing
Faculty of Medicine > Warwick Medical School
|Journal or Publication Title:||Human Brain Mapping|
|Publisher:||John Wiley and Sons|
|Official Date:||December 2009|
|Number of Pages:||9|
|Page Range:||pp. 4129-4137|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||National Institute of Health Research, UK, Wellcome Trust, Department of Health, UK|
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