Roberts, Owain Llyr, Holmes, Katherine, Müller, Jürgen, Cross, Darren A. E. and Cross, Michael J.. (2009) ERK5 and the regulation of endothelial cell function. Biochemical Society Transactions, Vol.37 (Part 6). pp. 1254-1259. ISSN 0300-5127

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Abstract

ERK5 (extracellular-signal-regulated kinase 5), also termed BMK1 [big MAPK1 (mitogen-activated protein kinase 1)], is the most recently discovered member of the MAPK family. it is expressed in a variety of tissues and is activated by a range of growth factors, cytokines and cellular stresses. Targeted deletion of Erk5 in mice has revealed that the ERK5 signalling cascade is critical for normal cardiovascular development and vascular integrity. in vitro studies have revealed that in endothelial cells, ERK5 is required for preventing apoptosis, mediating shear-stress signalling, regulating hypoxia, tumour angiogenesis and cell migration. This review focuses on our current understanding of the role of ERK5 in regulating endothelial cell function.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry
Divisions:	Faculty of Medicine > Warwick Medical School > Clinical Sciences Research Institute (CSRI) Faculty of Medicine > Warwick Medical School > Metabolic and Vascular Health Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	Biochemical Society Transactions
Publisher:	Portland Press Ltd
ISSN:	0300-5127
Date:	December 2009
Volume:	Vol.37
Number:	Part 6
Number of Pages:	6
Page Range:	pp. 1254-1259
Identification Number:	10.1042/BST0371254
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC), North West Cancer Research Fund, AstraZeneca
URI:	http://wrap.warwick.ac.uk/id/eprint/16825

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