Lalo, Ulyana, Andrew, Jemma, Palygin, Oleg and Pankratov, Yuriy. (2009) Ca2+-dependent modulation of GABA(A) and NMDA receptors by extracellular ATP: implication for function of tripartite synapse. Biochemical Society Transactions, Vol.374 (Part 6). pp. 1407-1411. ISSN 0300-5127

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Abstract

The importance of communication between neuronal and glial cells for brain function is recognized by a modern concept of 'tripartite synapse'. Astrocytes enwrap synapses and can modulate their activity by releasing gliotransmitters such as ATP, glutamate and D-serine. one of the regulatory pathways in the tripartite synapse is mediated by P2X purinoreceptors. Release of ATP from synaptic terminals and astrocytes activates Ca2+ influx via P2X purinoreceptors which co-localize with NMDA (N-methyl-D-aspartate) and GABA (gamma-aminobutyric acid) receptors and can modulate their activity via intracellular cascades which involve phosphatase II and PKA (protein kinase A).

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry
Divisions:	Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)
Journal or Publication Title:	Biochemical Society Transactions
Publisher:	Portland Press Ltd
ISSN:	0300-5127
Date:	December 2009
Volume:	Vol.374
Number:	Part 6
Number of Pages:	5
Page Range:	pp. 1407-1411
Identification Number:	10.1042/BST0371407
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC)
Grant number:	BB/F0221445 (BBSRC)
URI:	http://wrap.warwick.ac.uk/id/eprint/16826

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