Ca2+-dependent modulation of GABA(A) and NMDA receptors by extracellular ATP: implication for function of tripartite synapse
Lalo, Ulyana, Andrew, Jemma, Palygin, Oleg and Pankratov, Yuriy. (2009) Ca2+-dependent modulation of GABA(A) and NMDA receptors by extracellular ATP: implication for function of tripartite synapse. Biochemical Society Transactions, Vol.374 (Part 6). pp. 1407-1411. ISSN 0300-5127Full text not available from this repository.
Official URL: http://dx.doi.org/10.1042/BST0371407
The importance of communication between neuronal and glial cells for brain function is recognized by a modern concept of 'tripartite synapse'. Astrocytes enwrap synapses and can modulate their activity by releasing gliotransmitters such as ATP, glutamate and D-serine. one of the regulatory pathways in the tripartite synapse is mediated by P2X purinoreceptors. Release of ATP from synaptic terminals and astrocytes activates Ca2+ influx via P2X purinoreceptors which co-localize with NMDA (N-methyl-D-aspartate) and GABA (gamma-aminobutyric acid) receptors and can modulate their activity via intracellular cascades which involve phosphatase II and PKA (protein kinase A).
|Item Type:||Journal Article|
|Subjects:||Q Science > QD Chemistry|
|Divisions:||Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)|
|Journal or Publication Title:||Biochemical Society Transactions|
|Publisher:||Portland Press Ltd|
|Number of Pages:||5|
|Page Range:||pp. 1407-1411|
|Access rights to Published version:||Restricted or Subscription Access|
|Funder:||Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC)|
|Grant number:||BB/F0221445 (BBSRC)|
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