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Ca2+-dependent modulation of GABA(A) and NMDA receptors by extracellular ATP: implication for function of tripartite synapse

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Lalo, Ulyana, Andrew, Jemma, Palygin, Oleg and Pankratov, Yuriy (2009) Ca2+-dependent modulation of GABA(A) and NMDA receptors by extracellular ATP: implication for function of tripartite synapse. Biochemical Society Transactions, Vol.374 (Part 6). pp. 1407-1411. doi:10.1042/BST0371407

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Official URL: http://dx.doi.org/10.1042/BST0371407

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Abstract

The importance of communication between neuronal and glial cells for brain function is recognized by a modern concept of 'tripartite synapse'. Astrocytes enwrap synapses and can modulate their activity by releasing gliotransmitters such as ATP, glutamate and D-serine. one of the regulatory pathways in the tripartite synapse is mediated by P2X purinoreceptors. Release of ATP from synaptic terminals and astrocytes activates Ca2+ influx via P2X purinoreceptors which co-localize with NMDA (N-methyl-D-aspartate) and GABA (gamma-aminobutyric acid) receptors and can modulate their activity via intracellular cascades which involve phosphatase II and PKA (protein kinase A).

Item Type: Journal Article
Subjects: Q Science > QD Chemistry
Divisions: Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)
Journal or Publication Title: Biochemical Society Transactions
Publisher: Portland Press Ltd
ISSN: 0300-5127
Official Date: December 2009
Dates:
DateEvent
December 2009Published
Volume: Vol.374
Number: Part 6
Number of Pages: 5
Page Range: pp. 1407-1411
DOI: 10.1042/BST0371407
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
Funder: Biotechnology and Biological Sciences Research Council (Great Britain) (BBSRC)
Grant number: BB/F0221445 (BBSRC)

Data sourced from Thomson Reuters' Web of Knowledge

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