Stress hormones: physiological stress and regulation of metabolism
Kyrou, Ioannis and Tsigos, Constantine (2009) Stress hormones: physiological stress and regulation of metabolism. Current Opinion in Pharmacology, Vol.9 (No.6). pp. 787-793. ISSN 1471-4892Full text not available from this repository.
Official URL: http://dx.doi.org/10.1016/j.coph.2009.08.007
Stress, defined as a state of threatened homeostasis, mobilizes a complex spectrum of adaptive physiologic and behavioral responses that aim to re-establish the challenged body homeostasis. The hypothalamic-pituitary-ad renal (HPA) axis and the sympathetic nervous system (SNS) constitute the main effector pathways of the stress system, mediating its adaptive functions. In western societies, indices of stress correlate with increasing rates of both obesity and metabolic syndrome which have reached epidemic proportions. Recent data indicate that chronic stress, associated with mild hypercortisolemia and prolonged SNS activation, favors accumulation of visceral fat and contributes to the clinical presentation of visceral obesity, type 2 diabetes, and related cardiometabolic complications. Reciprocally, obesity promotes a systemic low-grade inflammation state, mediated by increased adipokine secretion, which can chronically stimulate the stress system.
|Item Type:||Journal Item|
|Subjects:||R Medicine > RS Pharmacy and materia medica|
|Divisions:||Faculty of Medicine > Warwick Medical School|
|Journal or Publication Title:||Current Opinion in Pharmacology|
|Publisher:||Elsevier Science Ltd.|
|Number of Pages:||7|
|Page Range:||pp. 787-793|
|Access rights to Published version:||Restricted or Subscription Access|
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