Kyrou, Ioannis and Tsigos, Constantine (2009) Stress hormones: physiological stress and regulation of metabolism. Current Opinion in Pharmacology, Vol.9 (No.6). pp. 787-793. ISSN 1471-4892

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Abstract

Stress, defined as a state of threatened homeostasis, mobilizes a complex spectrum of adaptive physiologic and behavioral responses that aim to re-establish the challenged body homeostasis. The hypothalamic-pituitary-ad renal (HPA) axis and the sympathetic nervous system (SNS) constitute the main effector pathways of the stress system, mediating its adaptive functions. In western societies, indices of stress correlate with increasing rates of both obesity and metabolic syndrome which have reached epidemic proportions. Recent data indicate that chronic stress, associated with mild hypercortisolemia and prolonged SNS activation, favors accumulation of visceral fat and contributes to the clinical presentation of visceral obesity, type 2 diabetes, and related cardiometabolic complications. Reciprocally, obesity promotes a systemic low-grade inflammation state, mediated by increased adipokine secretion, which can chronically stimulate the stress system.

Item Type:	Journal Item
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	Current Opinion in Pharmacology
Publisher:	Elsevier Science Ltd.
ISSN:	1471-4892
Date:	December 2009
Volume:	Vol.9
Number:	No.6
Number of Pages:	7
Page Range:	pp. 787-793
Identification Number:	10.1016/j.coph.2009.08.007
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
URI:	http://wrap.warwick.ac.uk/id/eprint/16860

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