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Performance and robustness analysis of control strategies for ameliorating cellular host-circuit interactions
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Darlington, Alexander P. S. and Bates, Declan G. (2022) Performance and robustness analysis of control strategies for ameliorating cellular host-circuit interactions. In: 2022 European Control Conference (ECC), London, United Kingdom, 12-15 Jul 2022. Published in: 2022 European Control Conference (ECC) doi:10.23919/ecc55457.2022.9837985 ISSN 9783907144077.
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WRAP-Performance-robustness-control-strategies-22.pdf - Accepted Version - Requires a PDF viewer. Download (1242Kb) | Preview |
Official URL: https://doi.org/10.23919/ecc55457.2022.9837985
Abstract
Recent work on engineering synthetic cellular circuitry has shown that non-regulatory interactions brought about through competition for shared gene expression re-sources, such as ribosomes, can result in degraded performance (where circuit behaviour deviates from design specifications) or even failure (qualitatively different functionality). Numerous feedback control strategies have been proposed to decouple co-expressed genes in simple genetic circuits; ranging from feedback within the circuit, resource allocation schemes and growth-based feedback. In this work, we utilise a whole cell mathematical model, which captures key gene expression trade-offs, to compare these control strategies for their ability to ame-liorate the impact of resource limitations, maintain growth and assess their robustness to host uncertainty and environmental variation.
| Item Type: | Conference Item (Paper) | |||||||||
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| Subjects: | Q Science > QH Natural history > QH426 Genetics | |||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | |||||||||
| SWORD Depositor: | Library Publications Router | |||||||||
| Library of Congress Subject Headings (LCSH): | Gene regulatory networks, Gene expression, Synthetic biology | |||||||||
| Journal or Publication Title: | 2022 European Control Conference (ECC) | |||||||||
| Publisher: | IEEE | |||||||||
| ISSN: | 9783907144077 | |||||||||
| Official Date: | 12 July 2022 | |||||||||
| Dates: |
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| DOI: | 10.23919/ecc55457.2022.9837985 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Reuse Statement (publisher, data, author rights): | © 2022 Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. | |||||||||
| Access rights to Published version: | Restricted or Subscription Access | |||||||||
| Date of first compliant deposit: | 7 November 2022 | |||||||||
| Date of first compliant Open Access: | 7 November 2022 | |||||||||
| RIOXX Funder/Project Grant: |
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| Conference Paper Type: | Paper | |||||||||
| Title of Event: | 2022 European Control Conference (ECC) | |||||||||
| Type of Event: | Conference | |||||||||
| Location of Event: | London, United Kingdom | |||||||||
| Date(s) of Event: | 12-15 Jul 2022 |
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