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Miscarriage syndrome : linking early pregnancy loss to obstetric and age-related disorders
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Bortoletto, Pietro, Lucas, Emma S., Melo, Pedro, Gallos, Ioannis D., Devall, Adam J., Bourne, Tom, Quenby, Siobhan, Bennett, Phillip R., Coomarasamy, Arri and Brosens, Jan J. (2022) Miscarriage syndrome : linking early pregnancy loss to obstetric and age-related disorders. EBioMedicine, 81 . 104134. doi:10.1016/j.ebiom.2022.104134 ISSN 2352-3964.
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WRAP-miscarriage-syndrome-linking-early-pregnancy-loss-obstetric-age-related-disorders-2022.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (509Kb) | Preview |
Official URL: http://dx.doi.org/10.1016/j.ebiom.2022.104134
Abstract
Upon embryo implantation, the uterine mucosa - the endometrium - transforms into a robust decidual matrix that accommodates the fetal placenta throughout pregnancy. This transition is driven by the differentiation of endometrial fibroblasts into specialised decidual cells. A synchronised influx of circulating natural killer (NK) cells and bone marrow-derived mesenchymal stem/progenitor cells (BM-MSC) is pivotal for decidual homeostasis and expansion in early pregnancy. We hypothesise that pathological signals interfering with the recruitment or activity of extrauterine cells at the maternal-fetal interface link miscarriage to subsequent adverse pregnancy outcomes, including further pregnancy losses and preterm labour. NK cells and BM-MSC are key homeostatic regulators in multiple tissues, pointing towards a shared aetiology between recurrent miscarriage and age-related disorders, including cardiometabolic disease. We propose the term ‘miscarriage syndrome’ to capture the health risks associated with miscarriage and discuss how this paradigm can inform clinical practice and accelerate the development of preventative strategies.
| Item Type: | Journal Article | ||||||||
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| Subjects: | R Medicine > RG Gynecology and obstetrics | ||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Miscarriage -- Research, Pregnancy -- Complications, Premature labor, Reproductive health | ||||||||
| Journal or Publication Title: | EBioMedicine | ||||||||
| Publisher: | Elsevier BV | ||||||||
| ISSN: | 2352-3964 | ||||||||
| Official Date: | July 2022 | ||||||||
| Dates: |
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| Volume: | 81 | ||||||||
| Article Number: | 104134 | ||||||||
| DOI: | 10.1016/j.ebiom.2022.104134 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||
| Date of first compliant deposit: | 9 September 2022 | ||||||||
| Date of first compliant Open Access: | 12 September 2022 |
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