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The DAPA-DIET study : metabolic response to Dapagliflozin combined with dietary carbohydrate restriction in patients with Type 2 Diabetes mellitus and obesity—a longitudinal cohort study
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Hanson, Petra, Randeva, Harpal S., Cuthbertson, D., O'Hare, Paul J., Parsons, Nicholas R., Chatha, Kamaljit , Reidy, G., Weickert, Martin O. and Barber, Thomas M. (2022) The DAPA-DIET study : metabolic response to Dapagliflozin combined with dietary carbohydrate restriction in patients with Type 2 Diabetes mellitus and obesity—a longitudinal cohort study. Endocrinology, Diabetes & Metabolism, 5 (6). e381. doi:10.1002/edm2.381 ISSN 2398-9238.
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Official URL: https://doi.org/10.1002/edm2.381
Abstract
The cardio-renal benefits of sodium glucose-like transporter 2 inhibitor (SGLT2i) therapies have been demonstrated in patients with and without type 2 diabetes. However, no studies have explored the long-term metabolic effects of SGLT2i, combined with dietary carbohydrate restriction. Our primary objective was to describe long-term changes in weight, energy expenditure, appetite and body composition after 12 months of Dapagliflozin therapy, with carbohydrate restriction, in people with type 2 diabetes and obesity. Our secondary objective was to assess changes in adiponectin and leptin.
Item Type: | Journal Article | ||||||||
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Subjects: | R Medicine > RC Internal medicine R Medicine > RM Therapeutics. Pharmacology |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Type 2 diabetes, Type 2 diabetes -- Diet therapy, Type 2 diabetes -- Treatment, Obesity , Reducing diets , Obesity -- Treatment | ||||||||
Journal or Publication Title: | Endocrinology, Diabetes & Metabolism | ||||||||
Publisher: | John Wiley & Sons | ||||||||
ISSN: | 2398-9238 | ||||||||
Official Date: | November 2022 | ||||||||
Dates: |
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Volume: | 5 | ||||||||
Number: | 6 | ||||||||
Article Number: | e381 | ||||||||
DOI: | 10.1002/edm2.381 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 1 November 2022 | ||||||||
Date of first compliant Open Access: | 1 November 2022 | ||||||||
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