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Glutamyl-tRNA as an intermediate in Glutamate conversions
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Verkamp, Elizabeth, Kumar, A. Madan, Lloyd, Adrian J. and Martins, Orlando (1994) Glutamyl-tRNA as an intermediate in Glutamate conversions. In: Söll, Dieter and RajBhandary, Uttam L., (eds.) tRNA: Structure, Biosynthesis, and Function. Washington DC: ASM Press, pp. 545-550. ISBN 9781555810733
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Official URL: https://doi.org/10.1128/9781555818333.ch27
Abstract
Since the discovery of initiator tRNA, a number of reactions have been found that involve modification of amino acids attached to tRNA. These reactions include well-understood processes like the formation of formylmethionyl-tRNA, which serves to initiate peptide chain formation in prokaryotes, or the synthesis of selenocysteine, which functions as the 21st amino acid. Less well understood are the conversions of glutamate. The first conversion serves for the formation of glutamate-1-semialdehyde, the initial precursor of porphyrins (e.g., chlorophylls and hemes). The other known reaction is a transamidation of glutamate attached to tRNAGln, which is a required intermediate in the formation of glutaminyl-tRNA in many organisms and organelles. These conversions of glutamate based on Glu-tRNA as intermediate are the topic of this chapter. Tetrapyrrole-containing compounds, such as hemes and chlorophylls, are essential components of respiratory and photosynthetic reactions. The porphyrin ring of these compounds is derived from eight molecules of 5-aminolevulinic acid (ALA), a precursor whose formation provides a key regulatory control point in heme and chlorophyll biosynthesis.
| Item Type: | Book Item | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
| Publisher: | ASM Press | ||||
| Place of Publication: | Washington DC | ||||
| ISBN: | 9781555810733 | ||||
| Book Title: | tRNA: Structure, Biosynthesis, and Function | ||||
| Editor: | Söll, Dieter and RajBhandary, Uttam L. | ||||
| Official Date: | 18 November 1994 | ||||
| Dates: |
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| Page Range: | pp. 545-550 | ||||
| DOI: | 10.1128/9781555818333.ch27 | ||||
| Status: | Not Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Description: | Chapter 27 |
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