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A de novo designed inhibitor of D-Ala-D-Ala ligase from E. coli
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Besong, Gilbert E., Bostock, Julieanne M., Stubbings, Will, Chopra, Ian, Roper, David I., Lloyd, Adrian J., Fishwick, Colin W. G. and Johnson, A. Peter (2005) A de novo designed inhibitor of D-Ala-D-Ala ligase from E. coli. Angewandte Chemie (International Edition), 44 (39). pp. 6403-6406. doi:10.1002/anie.200501662 ISSN 1433-7851.
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Besong et al (2005) Angew. Chem. Int. Ed. 44, 6403-6406.pdf - Published Version Embargoed item. Restricted access to Repository staff only - Requires a PDF viewer. Download (138Kb) |
Official URL: https://doi.org/10.1002/anie.200501662
Abstract
Blueprints for an inhibitor: The de novo molecular design program SPROUT was used in conjunction with the X-ray crystal structures of the bacterial enzymes DdlB and VanA to produce a novel enzyme-selective inhibitor template. Following short and efficient synthesis and in keeping with the design predictions, the resulting inhibitor showed useful levels of enzyme-selective inhibition.
| Item Type: | Journal Article | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||||
| Journal or Publication Title: | Angewandte Chemie (International Edition) | ||||||||
| Publisher: | Wiley | ||||||||
| ISSN: | 1433-7851 | ||||||||
| Official Date: | October 2005 | ||||||||
| Dates: |
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| Volume: | 44 | ||||||||
| Number: | 39 | ||||||||
| Page Range: | pp. 6403-6406 | ||||||||
| DOI: | 10.1002/anie.200501662 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| Date of first compliant deposit: | 3 October 2022 |
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