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Oogenesis and cell death in human prenatal ovaries : what are the criteria for oocyte selection?
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Hartshorne, G. M., Lyrakou, S., Hamoda, H., Oloto, E. and Ghafari, F. (2009) Oogenesis and cell death in human prenatal ovaries : what are the criteria for oocyte selection? Molecular Human Reproduction, Vol.15 (No.12). pp. 805-819. ISSN 1360-9947
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Official URL: http://dx.doi.org/10.1093/molehr/gap055
Abstract
Prenatal oogenesis produces hundreds of thousands of oocytes, most of which are discarded through apoptosis before birth. Despite this large-scale selection, the survivors do not constitute a perfect population, and the factors at the cellular level that result in apoptosis or survival of any individual oocyte are largely unknown. What then are the selection criteria that determine the size and quality of the ovarian reserve in women? This review focuses on new data at the cellular level, on human prenatal oogenesis, offering clues about the importance of the timing of entry to meiotic prophase I by linking the stages and progress through MPI with the presence or absence of apoptotic markers. The characteristics and responsiveness of cultured human fetal ovarian tissue at different gestational ages to growth factor supplementation and the impact of meiotic abnormalities upon apoptotic markers are discussed. Future work will require the use of a tissue culture model of prenatal oogenesis in order to investigate the fate of individual live oocytes at different stages of development.
| Item Type: | Journal Item |
|---|---|
| Subjects: | Q Science > QH Natural history > QH301 Biology R Medicine > RG Gynecology and obstetrics |
| Divisions: | Faculty of Medicine > Warwick Medical School > Reproductive Health Faculty of Medicine > Warwick Medical School |
| Journal or Publication Title: | Molecular Human Reproduction |
| Publisher: | Oxford University Press |
| ISSN: | 1360-9947 |
| Date: | December 2009 |
| Volume: | Vol.15 |
| Number: | No.12 |
| Number of Pages: | 15 |
| Page Range: | pp. 805-819 |
| Identification Number: | 10.1093/molehr/gap055 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| Funder: | The Royal Society, The Wellcome Trust, Wellbeing of Women, The Sanofi Winthrop Foundation, The University of Warwick, Centre for Reproductive Medicine |
| URI: | http://wrap.warwick.ac.uk/id/eprint/16973 |
Data sourced from Thomson Reuters' Web of Knowledge
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