The Library
Enhanced flow synthesis of small molecules by in-line integration of sequential catalysis and benchtop twin-column continuous chromatography
Tools
Sivo, Alessandra, Kim, Tae Keun, Ruta, Vincenzo, Luisi, Renzo, Osorio-Tejada, Jose, Escriba-Gelonch, Marc, Hessel, Volker, Sponchioni, Mattia and Vilé, Gianvito (2022) Enhanced flow synthesis of small molecules by in-line integration of sequential catalysis and benchtop twin-column continuous chromatography. Reaction Chemistry & Engineering, 7 (12). pp. 2650-2658. doi:10.1039/d2re00242f ISSN 2058-9883.
|
PDF
WRAP-Enhanced-flow-synthesis-small-molecules-inline-integration-sequential-catalysis-22.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution Non-commercial. Download (1176Kb) | Preview |
Official URL: https://doi.org/10.1039/d2re00242f
Abstract
We report an improved approach for the integration of flow synthesis and continuous chromatography, for applications in the end-to-end preparation of pharmaceutically-relevant small molecules. It involves the combination of sequential microreactors and twin-column counter-current chromatography based on the often-used C18 columns. The column loading method ensures that the product breaking through a fully loaded first column is loaded onto the second one, avoiding waste of precious material and technological complexity associated with the use of four-to-six columns typical of simulated moving bed chromatography. The system was applied to synthesize biphenyl via Suzuki–Miyaura reaction, and was also demonstrated for other structurally-different compounds. Compared to the discontinuous and other traditional approaches, our method leads to higher isolated yields (ca. +60%), higher productivity (ca. +30%), and reduced solvent consumption (ca. −80%). A circularity and life-cycle analysis was also conducted to demonstrate the environmental benefits of the flow process.
Item Type: | Journal Article | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Subjects: | Q Science > QD Chemistry T Technology > TP Chemical technology |
|||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Engineering > Engineering | |||||||||||||||
SWORD Depositor: | Library Publications Router | |||||||||||||||
Library of Congress Subject Headings (LCSH): | Fluid dynamics, Biomolecules, Chemical Engineering, Catalysis | |||||||||||||||
Journal or Publication Title: | Reaction Chemistry & Engineering | |||||||||||||||
Publisher: | Royal Society of Chemistry | |||||||||||||||
ISSN: | 2058-9883 | |||||||||||||||
Official Date: | 1 December 2022 | |||||||||||||||
Dates: |
|
|||||||||||||||
Volume: | 7 | |||||||||||||||
Number: | 12 | |||||||||||||||
Page Range: | pp. 2650-2658 | |||||||||||||||
DOI: | 10.1039/d2re00242f | |||||||||||||||
Status: | Peer Reviewed | |||||||||||||||
Publication Status: | Published | |||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||
Date of first compliant deposit: | 28 October 2022 | |||||||||||||||
Date of first compliant Open Access: | 28 October 2022 | |||||||||||||||
RIOXX Funder/Project Grant: |
|
|||||||||||||||
Related URLs: |
Request changes or add full text files to a record
Repository staff actions (login required)
View Item |
Downloads
Downloads per month over past year