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Use of ion mobility mass spectrometry and a collision cross-section algorithm to study an organometallic ruthenium anticancer complex and its adducts with a DNA oligonucleotide
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Williams, Jonathan P., Lough, Julie Ann, Campuzano, Iain, Richardson, K. (Keith) and Sadler, P. J. (2009) Use of ion mobility mass spectrometry and a collision cross-section algorithm to study an organometallic ruthenium anticancer complex and its adducts with a DNA oligonucleotide. Rapid Communications in Mass Spectrometry, Vol.23 (No.22). pp. 3563-3569. doi:10.1002/rcm.4285 ISSN 09514198.
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Official URL: http://dx.doi.org/10.1002/rcm.4285
Abstract
We report the development of an enhanced algorithm for the calculation of collision cross-sections in combination with Travelling-Wave ion mobility mass spectrometry technology and its optimisation and evaluation through the analysis of an organoruthenium anticancer complex [(eta(6)-biphenyl)Ru-II(en)Cl](+). Excellent agreement was obtained between the experimentally determined and theoretically determined collision cross-sections of the complex and its major product ion formed via collision-induced dissociation. Collision cross-sections were also experimentally determined for adducts of this ruthenium complex with the single-stranded oligonucleotide hexamer d(CACGTG). Ion mobility tandem mass spectrometry measurements have allowed the binding sites for ruthenium on the oligonucleotide to be determined. Copyright (D) 2009 John Wiley & Sons, Ltd.
Item Type: | Journal Article | ||||
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Subjects: | Q Science > QC Physics Q Science > QD Chemistry Q Science > QP Physiology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||
Library of Congress Subject Headings (LCSH): | Organometallic compounds -- Therapeutic use, Ruthenium compounds -- Therapeutic use, Antineoplastic agents, Ion mobility spectroscopy, Mass spectrometry, Oligonucleotides, DNA adducts, Algorithms, Cross sections (Nuclear physics) | ||||
Journal or Publication Title: | Rapid Communications in Mass Spectrometry | ||||
Publisher: | John Wiley & Sons Ltd. | ||||
ISSN: | 09514198 | ||||
Official Date: | November 2009 | ||||
Dates: |
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Volume: | Vol.23 | ||||
Number: | No.22 | ||||
Number of Pages: | 7 | ||||
Page Range: | pp. 3563-3569 | ||||
DOI: | 10.1002/rcm.4285 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Funder: | University of Warwick |
Data sourced from Thomson Reuters' Web of Knowledge
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