Williams, Jonathan P., Lough, Julie Ann, Campuzano, Iain, Richardson, K. (Keith) and Sadler, P. J.. (2009) Use of ion mobility mass spectrometry and a collision cross-section algorithm to study an organometallic ruthenium anticancer complex and its adducts with a DNA oligonucleotide. Rapid Communications in Mass Spectrometry, Vol.23 (No.22). pp. 3563-3569. ISSN 09514198

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Abstract

We report the development of an enhanced algorithm for the calculation of collision cross-sections in combination with Travelling-Wave ion mobility mass spectrometry technology and its optimisation and evaluation through the analysis of an organoruthenium anticancer complex [(eta(6)-biphenyl)Ru-II(en)Cl](+). Excellent agreement was obtained between the experimentally determined and theoretically determined collision cross-sections of the complex and its major product ion formed via collision-induced dissociation. Collision cross-sections were also experimentally determined for adducts of this ruthenium complex with the single-stranded oligonucleotide hexamer d(CACGTG). Ion mobility tandem mass spectrometry measurements have allowed the binding sites for ruthenium on the oligonucleotide to be determined. Copyright (D) 2009 John Wiley & Sons, Ltd.

Item Type:	Journal Article
Subjects:	Q Science > QC Physics Q Science > QD Chemistry Q Science > QP Physiology
Divisions:	Faculty of Science > Chemistry
Library of Congress Subject Headings (LCSH):	Organometallic compounds -- Therapeutic use, Ruthenium compounds -- Therapeutic use, Antineoplastic agents, Ion mobility spectroscopy, Mass spectrometry, Oligonucleotides, DNA adducts, Algorithms, Cross sections (Nuclear physics)
Journal or Publication Title:	Rapid Communications in Mass Spectrometry
Publisher:	John Wiley & Sons Ltd.
ISSN:	09514198
Date:	November 2009
Volume:	Vol.23
Number:	No.22
Number of Pages:	7
Page Range:	pp. 3563-3569
Identification Number:	10.1002/rcm.4285
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Funder:	University of Warwick
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URI:	http://wrap.warwick.ac.uk/id/eprint/17000

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