Nicodemi, Mario, de Candia, Antonio and Coniglio, Antonio. (2009) Aggregation of fibrils and plaques in amyloid molecular systems. Physical Review E (Statistical, Nonlinear, and Soft Matter Physics), Vol.80 (No.4 Part 1). Article no. 041914. ISSN 1539-3755

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Abstract

Amyloidlike proteins form highly organized aggregates, such as fibrils and plaques, preceded by the assembly of a wide range of unstructured oligomers and protofibrils. Despite their importance in a number of human neurodegenerative diseases, a comprehensive understanding of their kinetics and thermodynamics is still missing. We investigate, by computer simulations, a realistic model of amyloid molecules interacting via the experimentally determined Derjaguin-Landau-Verwey-Overbeek potential and derive its phase diagram. We show that fibrils and plaques, along with their precursors, correspond to different equilibrium and metastable thermodynamics phases and discuss the dynamical mechanisms leading to the nucleation and self-assembly of large scale structures.

Item Type:	Journal Article
Subjects:	Q Science > QC Physics
Divisions:	Faculty of Science > Centre for Complexity Science Faculty of Science > Physics
Journal or Publication Title:	Physical Review E (Statistical, Nonlinear, and Soft Matter Physics)
Publisher:	American Physical Society
ISSN:	1539-3755
Official Date:	October 2009
Dates:	Date Event October 2009 Published
Volume:	Vol.80
Number:	No.4 Part 1
Number of Pages:	4
Page Range:	Article no. 041914
DOI:	10.1103/PhysRevE.80.041914
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
URI:	http://wrap.warwick.ac.uk/id/eprint/17042

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