Aggregation of fibrils and plaques in amyloid molecular systems
Nicodemi, Mario, de Candia, Antonio and Coniglio, Antonio. (2009) Aggregation of fibrils and plaques in amyloid molecular systems. Physical Review E (Statistical, Nonlinear, and Soft Matter Physics), Vol.80 (No.4 Part 1). Article no. 041914. ISSN 1539-3755Full text not available from this repository.
Official URL: http://dx.doi.org/10.1103/PhysRevE.80.041914
Amyloidlike proteins form highly organized aggregates, such as fibrils and plaques, preceded by the assembly of a wide range of unstructured oligomers and protofibrils. Despite their importance in a number of human neurodegenerative diseases, a comprehensive understanding of their kinetics and thermodynamics is still missing. We investigate, by computer simulations, a realistic model of amyloid molecules interacting via the experimentally determined Derjaguin-Landau-Verwey-Overbeek potential and derive its phase diagram. We show that fibrils and plaques, along with their precursors, correspond to different equilibrium and metastable thermodynamics phases and discuss the dynamical mechanisms leading to the nucleation and self-assembly of large scale structures.
|Item Type:||Journal Article|
|Subjects:||Q Science > QC Physics|
|Divisions:||Faculty of Science > Centre for Complexity Science
Faculty of Science > Physics
|Journal or Publication Title:||Physical Review E (Statistical, Nonlinear, and Soft Matter Physics)|
|Publisher:||American Physical Society|
|Number:||No.4 Part 1|
|Number of Pages:||4|
|Page Range:||Article no. 041914|
|Access rights to Published version:||Restricted or Subscription Access|
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