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Social anxiety in neurodevelopmental disorders : the case of fragile X syndrome
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Crawford, Hayley (2023) Social anxiety in neurodevelopmental disorders : the case of fragile X syndrome. American Journal on Intellectual and Developmental Disabilities, 128 (4). pp. 302-318. doi:10.1352/1944-7558-128.4.302 ISSN 1944-7515.
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Official URL: https://doi.org/10.1352/1944-7558-128.4.302
Abstract
Despite significant advances in understanding and treating social anxiety in the general population, progress in this area lags behind for individuals with intellectual disability. Fragile X syndrome is the most common cause of inherited intellectual disability and is associated with an elevated prevalence rate of social anxiety. The phenotype of fragile X syndrome encompasses multiple clinically-significant characteristics that are posed as risk markers for social anxiety in other populations. Here, evidence is reviewed that points to physiological hyperarousal, sensory sensitivity, emotion dysregulation, cognitive inflexibility, and intolerance of uncertainty as primary candidates for underlying mechanisms of heightened social anxiety in fragile X syndrome. A multi-level model is presented that provides a framework for future research to test associations.
Item Type: | Journal Article | ||||||
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Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry | ||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School | ||||||
Library of Congress Subject Headings (LCSH): | Fragile X syndrome, Social phobia, Anxiety, Developmental disabilities, Intellectual disability | ||||||
Journal or Publication Title: | American Journal on Intellectual and Developmental Disabilities | ||||||
Publisher: | American Association on Intellectual and Developmental Disabilities | ||||||
ISSN: | 1944-7515 | ||||||
Official Date: | 20 July 2023 | ||||||
Dates: |
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Volume: | 128 | ||||||
Number: | 4 | ||||||
Page Range: | pp. 302-318 | ||||||
DOI: | 10.1352/1944-7558-128.4.302 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||
Date of first compliant deposit: | 24 October 2022 | ||||||
Date of first compliant Open Access: | 24 October 2022 | ||||||
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