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Competition between cell types under cell cycle regulation with apoptosis
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Li, Jintao, Schnyder, Simon K., Turner, Matthew S. and Yamamoto, Ryoichi (2022) Competition between cell types under cell cycle regulation with apoptosis. Physical Review Research, 4 (3). 033156. doi:10.1103/PhysRevResearch.4.033156 ISSN 2643-1564.
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Official URL: http://dx.doi.org/10.1103/PhysRevResearch.4.033156
Abstract
Competition between different cell types plays a crucial role in bacterial ecology, developmental biology, and tumor growth. We study how cells compete in 2D by using both a mean field theory and particle-based simulations. We employ a mechanical model that incorporates a stylized form of cell cycle regulation to control cell division events. This is extended to treat multiple cell types with different rates of programed cell death (apoptosis) and characteristic cell-cycle control pressures. Analytic predictions for the invasion speed and the coexistence line are in agreement with simulations. Synchronization in the cell division/apoptosis events can emerge, leading to oscillations in pressure and cell-cycle activity. We also study the invasion or elimination of small (pre)cancerous colonies. We show how a Laplace pressure at the colony interface, here controlled by differential cell adhesion, shifts the coexistence line; there are cell types that can invade when starting from a large colony but will be eliminated if the colony is small.
| Item Type: | Journal Article | |||||||||||||||
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| Subjects: | Q Science > QH Natural history > QH301 Biology | |||||||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Physics | |||||||||||||||
| Library of Congress Subject Headings (LCSH): | Cells, Cell cycle -- Regulation, Apoptosis, Cytology -- Research, Cell proliferation | |||||||||||||||
| Journal or Publication Title: | Physical Review Research | |||||||||||||||
| Publisher: | American Physical Society | |||||||||||||||
| ISSN: | 2643-1564 | |||||||||||||||
| Official Date: | 29 August 2022 | |||||||||||||||
| Dates: |
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| Volume: | 4 | |||||||||||||||
| Number: | 3 | |||||||||||||||
| Number of Pages: | 6 | |||||||||||||||
| Article Number: | 033156 | |||||||||||||||
| DOI: | 10.1103/PhysRevResearch.4.033156 | |||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||
| Publication Status: | Published | |||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||
| Date of first compliant deposit: | 25 October 2022 | |||||||||||||||
| Date of first compliant Open Access: | 27 October 2022 | |||||||||||||||
| RIOXX Funder/Project Grant: |
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