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Health-related quality-of-life outcomes of very preterm or very low birth weight adults : evidence from an individual participant data meta-analysis
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(2023) Health-related quality-of-life outcomes of very preterm or very low birth weight adults : evidence from an individual participant data meta-analysis. PharmacoEconomics, 41 . pp. 93-105. doi:10.1007/s40273-022-01201-2 ISSN 1170-7690.
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WRAP-Health-related-quality-of-life-outcomes-of-very-preterm-or-very-low-birth-weight-adults-2022.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons: Attribution-Noncommercial 4.0. Download (823Kb) | Preview |
Official URL: http://dx.doi.org/10.1007/s40273-022-01201-2
Abstract
Background and Objective
Assessment of health-related quality of life for individuals born very preterm and/or low birthweight (VP/VLBW) offers valuable complementary information alongside biomedical assessments. However, the impact of VP/VLBW status on health-related quality of life in adulthood is inconclusive. The objective of this study was to examine associations between VP/VLBW status and preference-based health-related quality-of-life outcomes in early adulthood.
Methods
Individual participant data were obtained from five prospective cohorts of individuals born VP/VLBW and controls contributing to the ‘Research on European Children and Adults Born Preterm’ Consortium. The combined dataset included over 2100 adult VP/VLBW survivors with an age range of 18–29 years. The main exposure was defined as birth before 32 weeks’ gestation (VP) and/or birth weight below 1500 g (VLBW). Outcome measures included multi-attribute utility scores generated by the Health Utilities Index Mark 3 and the Short Form 6D. Data were analysed using generalised linear mixed models in a one-step approach using fixed-effects and random-effects models.
Results
VP/VLBW status was associated with a significant difference in the Health Utilities Index Mark 3 multi-attribute utility score of − 0.06 (95% confidence interval − 0.08, − 0.04) in comparison to birth at term or at normal birthweight; this was not replicated for the Short Form 6D. Impacted functional domains included vision, ambulation, dexterity and cognition. VP/VLBW status was not associated with poorer emotional or social functioning, or increased pain.
Conclusions
VP/VLBW status is associated with lower overall health-related quality of life in early adulthood, particularly in terms of physical and cognitive functioning. Further studies that estimate the effects of VP/VLBW status on health-related quality-of-life outcomes in mid and late adulthood are needed.
Item Type: | Journal Article | |||||||||||||||||||||||||||
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Subjects: | H Social Sciences > HN Social history and conditions. Social problems. Social reform R Medicine > RJ Pediatrics |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Science > Psychology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Premature infants, Premature infants -- Development, Premature infants -- Psychology, Prematurely born children , Prematurely born children -- Development, Prematurely born children -- Psychology, Quality of life , Quality of life -- Health aspects , Birth weight, Low | |||||||||||||||||||||||||||
Journal or Publication Title: | PharmacoEconomics | |||||||||||||||||||||||||||
Publisher: | Springer | |||||||||||||||||||||||||||
ISSN: | 1170-7690 | |||||||||||||||||||||||||||
Official Date: | January 2023 | |||||||||||||||||||||||||||
Dates: |
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Volume: | 41 | |||||||||||||||||||||||||||
Page Range: | pp. 93-105 | |||||||||||||||||||||||||||
DOI: | 10.1007/s40273-022-01201-2 | |||||||||||||||||||||||||||
Status: | Peer Reviewed | |||||||||||||||||||||||||||
Publication Status: | Published | |||||||||||||||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||||||||||||||
Date of first compliant deposit: | 26 October 2022 | |||||||||||||||||||||||||||
Date of first compliant Open Access: | 28 October 2022 | |||||||||||||||||||||||||||
RIOXX Funder/Project Grant: |
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