
The Library
Surfactancy in a tadpole model of proteins
Tools
Dyer, Oliver T. and Ball, Robin (2022) Surfactancy in a tadpole model of proteins. Journal of The Royal Society Interface, 19 (195). 20220172. doi:10.1098/rsif.2022.0172 ISSN 1742-5689.
|
PDF
WRAP-surfactancy-tadpole-model-proteins-Ball-2022.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1837Kb) | Preview |
Official URL: http://dx.doi.org/10.1098/rsif.2022.0172
Abstract
We model the environment of eukaryotic nuclei by representing macromolecules by only their entropic properties, with globular molecules represented by spherical colloids and flexible molecules by polymers. We put particular focus on proteins with both globular and intrinsically disordered regions, which we represent with ‘tadpole’ constructed by grafting single polymers and colloids together. In Monte Carlo simulations, we find these tadpoles support phase separation via depletion flocculation, and demonstrate several surfactant behaviours, including being found preferentially at interfaces and forming micelles in single phase solution. Furthermore, the model parameters can be tuned to give a tadpole a preference for either bulk phase. However, we find entropy too weak to drive these behaviours by itself at likely biological concentrations.
Item Type: | Journal Article | ||||||
---|---|---|---|---|---|---|---|
Subjects: | Q Science > QH Natural history > QH301 Biology T Technology > TP Chemical technology |
||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Physics | ||||||
Library of Congress Subject Headings (LCSH): | Surface active agents, Separation (Technology), Eukaryotic cells -- Research, Proteins -- Structure, Carrier proteins, Biochemistry, Life sciences -- Research | ||||||
Journal or Publication Title: | Journal of The Royal Society Interface | ||||||
Publisher: | The Royal Society Publishing | ||||||
ISSN: | 1742-5689 | ||||||
Official Date: | 5 October 2022 | ||||||
Dates: |
|
||||||
Volume: | 19 | ||||||
Number: | 195 | ||||||
Article Number: | 20220172 | ||||||
DOI: | 10.1098/rsif.2022.0172 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
Date of first compliant deposit: | 26 October 2022 | ||||||
Date of first compliant Open Access: | 28 October 2022 | ||||||
RIOXX Funder/Project Grant: |
|
||||||
Related URLs: |
Request changes or add full text files to a record
Repository staff actions (login required)
![]() |
View Item |
Downloads
Downloads per month over past year