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Shear induced diffusion of platelets revisited
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Kotsalos, Christos, Raynaud, Franck, Lätt, Jonas, Dutta, Ritabrata, Dubois, Frank, Zouaoui Boudjeltia, Karim and Chopard, Bastien (2022) Shear induced diffusion of platelets revisited. Frontiers in Physiology, 13 . 985905. doi:10.3389/fphys.2022.985905 ISSN 1664-042X.
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Official URL: https://doi.org/10.3389/fphys.2022.985905
Abstract
The transport of platelets in blood is commonly assumed to obey an advection-diffusion equation with a diffusion constant given by the so-called Zydney-Colton theory. Here we reconsider this hypothesis based on experimental observations and numerical simulations including a fully resolved suspension of red blood cells and platelets subject to a shear. We observe that the transport of platelets perpendicular to the flow can be characterized by a non-trivial distribution of velocities with and exponential decreasing bulk, followed by a power law tail. We conclude that such distribution of velocities leads to diffusion of platelets about two orders of magnitude higher than predicted by Zydney-Colton theory. We tested this distribution with a minimal stochastic model of platelets deposition to cover space and time scales similar to our experimental results, and confirm that the exponential-powerlaw distribution of velocities results in a coefficient of diffusion significantly larger than predicted by the Zydney-Colton theory.
Item Type: | Journal Article | |||||||||||||||
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Subjects: | Q Science > QP Physiology | |||||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Statistics | |||||||||||||||
SWORD Depositor: | Library Publications Router | |||||||||||||||
Library of Congress Subject Headings (LCSH): | Blood platelets, Blood platelet disorders, Body fluid flow -- Mathematical models | |||||||||||||||
Journal or Publication Title: | Frontiers in Physiology | |||||||||||||||
Publisher: | Frontiers Research Foundation | |||||||||||||||
ISSN: | 1664-042X | |||||||||||||||
Official Date: | 13 October 2022 | |||||||||||||||
Dates: |
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Volume: | 13 | |||||||||||||||
Number of Pages: | 9 | |||||||||||||||
Article Number: | 985905 | |||||||||||||||
DOI: | 10.3389/fphys.2022.985905 | |||||||||||||||
Status: | Peer Reviewed | |||||||||||||||
Publication Status: | Published | |||||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||
Date of first compliant deposit: | 22 November 2022 | |||||||||||||||
Date of first compliant Open Access: | 22 November 2022 | |||||||||||||||
RIOXX Funder/Project Grant: |
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