Dale, Nicholas and Frenguelli, Bruno G. (2009) Release of adenosine and ATP during ischemia and epilepsy. Current Neuropharmacology, Vol.7 (No.3). pp. 160-179. ISSN 1570-159X

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Abstract

Eighty years ago Drury & Szent-Gyorgyi described the actions of adenosine, AMP (adenylic acid) and ATP (pyrophosphoric or diphosphoric ester of adenylic acid) on the mammalian cardiovascular system, skeletal muscle, intestinal and urinary systems. Since then considerable insight has been gleaned on the means by which these compounds act, not least of which in the distinction between the two broad classes of their respective receptors, with their many subtypes, and the ensuing diversity in cellular consequences their activation invokes. These myriad actions are of course predicated on the release of the purines into the extracellular milieu, but, surprisingly, there is still considerable ambiguity as to how this occurs in various physiological and pathophysiological conditions. In this review we summarise the release of ATP and adenosine during seizures and cerebral ischemia and discuss mechanisms by which the purines adenosine and ATP may be released from cells in the CNS under these conditions.

Item Type:	Journal Item
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry R Medicine > RS Pharmacy and materia medica
Divisions:	Faculty of Science > Life Sciences (2010- ) > Biological Sciences ( -2010)
Journal or Publication Title:	Current Neuropharmacology
Publisher:	Bentham Science Publishers Ltd.
ISSN:	1570-159X
Date:	September 2009
Volume:	Vol.7
Number:	No.3
Number of Pages:	20
Page Range:	pp. 160-179
Identification Number:	10.2174/157015909789152146
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Open Access
Funder:	Epilepsy Research UK, Medical Research Council, Research into Ageing, Wellcome Trust
URI:	http://wrap.warwick.ac.uk/id/eprint/17061

Data sourced from Thomson Reuters' Web of Knowledge

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