The Library
The eBRAIN study : the impact of early adversity on trajectories of brain maturation and mental health in young adolescents : a prospective cohort study
Tools
Tools
Tools
Pollard, Rebecca, Chen, Pei Jung, Mackes, Nuria, Lawrence, Andrew J., Ma, Xuemei, Matter, Maryam, Kretzer, Svenja, Morgan, Craig, Harding, Seeromanie, Schumann, Gunter, Pariante, Carmine, Mehta, Mitul, Montana, Giovanni, Nosarti, Chiara, Desrivieres, Sylvane, Rodriguez-Mateos, Ana and Dazzan, Paola (2022) The eBRAIN study : the impact of early adversity on trajectories of brain maturation and mental health in young adolescents : a prospective cohort study. Brain, Behavior, & Immunity - Health, 26 . 100539. doi:10.1016/j.bbih.2022.100539 ISSN 2666-3546.
|
PDF
1-s2.0-S2666354622001296-main.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. Download (408Kb) | Preview |
Official URL: https://doi.org/10.1016/j.bbih.2022.100539
Abstract
Introduction
More than 1 in 10 people are thought to experience a mental health problem during adolescence, with most adult psychopathology beginning during this time. Experiences of stress or adversity during childhood are important risk factors for poorer mental health outcomes and are also associated with alterations in neurodevelopment. There is evidence to suggest that this relationship is mediated by inflammation and the immune system. The eBRAIN study (The Impact of Early Adversity on Trajectories of Brain Maturation and Mental Health in Young Adolescents) will assess how early life adversity might affect trajectories of brain development throughout adolescence, whether these neurobiological changes are associated with psychopathology, and if they can potentially be explained by an activation of the immune system.
Methods
A cohort of 220 adolescents between the ages of 11–14 will be recruited into this study. Each participant will complete three study visits, each one year apart, at the Institute of Psychiatry, Psychology and Neuroscience, King's College London, London (UK). At each study visit, they will be assessed with structural and functional MRI scans, biological sample collection as well as questionnaires and interviews to collect demographic information, assess experiences of adversity, and details of psychopathology. The study will also collect information about factors such as diet and nutrition, physical exercise, and cognition.
Ethics and dissemination
Ethical approval for this study has been received by King's College London Research Ethics Committee (REC reference: HR-18/19–9033). Findings from the study will be published in peer-reviewed journals and disseminated at national and international conferences. Patient and public involvement (PPI) is an important component of the study, ‘Study Champions’ recruited from participants, their parents and teachers at collaborating schools have been invited to take an active role in study governance and dissemination.
| Item Type: | Journal Article | |||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Subjects: | B Philosophy. Psychology. Religion > BF Psychology R Medicine > RJ Pediatrics |
|||||||||||||||||||||||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Statistics Faculty of Science, Engineering and Medicine > Engineering > WMG (Formerly the Warwick Manufacturing Group) |
|||||||||||||||||||||||||||
| SWORD Depositor: | Library Publications Router | |||||||||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Youth -- Mental health -- Great Britain, Youth development -- Great Britain, Adolescent psychology -- Great Britain | |||||||||||||||||||||||||||
| Journal or Publication Title: | Brain, Behavior, & Immunity - Health | |||||||||||||||||||||||||||
| Publisher: | Elsevier | |||||||||||||||||||||||||||
| ISSN: | 2666-3546 | |||||||||||||||||||||||||||
| Official Date: | December 2022 | |||||||||||||||||||||||||||
| Dates: |
|
|||||||||||||||||||||||||||
| Volume: | 26 | |||||||||||||||||||||||||||
| Article Number: | 100539 | |||||||||||||||||||||||||||
| DOI: | 10.1016/j.bbih.2022.100539 | |||||||||||||||||||||||||||
| Status: | Peer Reviewed | |||||||||||||||||||||||||||
| Publication Status: | Published | |||||||||||||||||||||||||||
| Reuse Statement (publisher, data, author rights): | ** Article version: AM ** From Elsevier via Jisc Publications Router ** History: accepted 22-10-2022; issued 28-10-2022. ** Licence for AM version of this article starting on 22-10-2022: http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||||||||||||||||||||||
| Access rights to Published version: | Open Access (Creative Commons) | |||||||||||||||||||||||||||
| Date of first compliant deposit: | 28 November 2022 | |||||||||||||||||||||||||||
| Date of first compliant Open Access: | 28 November 2022 | |||||||||||||||||||||||||||
| RIOXX Funder/Project Grant: |
|
|||||||||||||||||||||||||||
| Related URLs: |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
Downloads
Downloads per month over past year
